Reactome | Interaction of integrin alphaVbeta3 with von Willbrand Factor

Interaction of integrin alphaVbeta3 with von Willbrand Factor

Stable Identifier

R-HSA-265425

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Interaction of integrin alphaVbeta3 with von Willbrand Factor

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Integrin alphaVbeta3 interacts with von Willebrand factor (vWF) on the RGD motif (1744-1746 residues) present on the mature vWF subunit.

Literature References

PubMed ID	Title	Journal	Year
7505120	Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor Lu, X, Denis, C, Meyer, D, Baruch, D, Williams, JA	Blood	1993