Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2)

Stable Identifier
R-HSA-265427
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2)
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Integrin alphaVbeta3 receptor has been implicated in various physiological and pathological responses, including bone density, angiogenesis, apoptosis, tumor growth and metastasis.
Bone sialoprotein (BSP) is a significant component of the bone extracellular matrix and plays an important role in bone resorption and osteoclast formation. BSP is considered as an important physiological ligand of alphaVbeta3 for osteoclast adhesion in bone development and mineralization.

Literature References
PubMed ID Title Journal Year
10640428 Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein

Byzova, TV, Kim, W, Midura, RJ, Plow, EF

Exp Cell Res 2000
Participants
Input
Output
Participant Of
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Orthologous Events
Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Canis familiaris)
Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Mus musculus)
Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Rattus norvegicus)
Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Sus scrofa)
Authored
Geiger, B  (2008-05-07)
Horwitz, AR  (2008-05-07)
Reviewed
Yamada, KM  (2008-05-07)
Humphries, MJ  (2008-05-07)
Hynes, R  (2008-05-07)
Created
Garapati, P V  (2008-04-18)