Integrin alphaVbeta3 receptor has been implicated in various physiological and pathological responses, including bone density, angiogenesis, apoptosis, tumor growth and metastasis. Bone sialoprotein (BSP) is a significant component of the bone extracellular matrix and plays an important role in bone resorption and osteoclast formation. BSP is considered as an important physiological ligand of alphaVbeta3 for osteoclast adhesion in bone development and mineralization.
Midura, RJ, Kim, W, Plow, EF, Byzova, TV
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