Reactome | Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2)

Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2)

Stable Identifier

R-HSA-265427

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2)

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Integrin alphaVbeta3 receptor has been implicated in various physiological and pathological responses, including bone density, angiogenesis, apoptosis, tumor growth and metastasis.
Bone sialoprotein (BSP) is a significant component of the bone extracellular matrix and plays an important role in bone resorption and osteoclast formation. BSP is considered as an important physiological ligand of alphaVbeta3 for osteoclast adhesion in bone development and mineralization.

Literature References

PubMed ID	Title	Journal	Year
10640428	Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein Midura, RJ, Kim, W, Plow, EF, Byzova, TV	Exp Cell Res	2000