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Interaction of integrin alpha9beta1 with VCAM1
Stable Identifier
R-HSA-265428
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Interaction of integrin alpha9beta1 with VCAM1 (Homo sapiens)
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Integrin alpha9beta1 is widely expressed on smooth muscle, epithelial cells, and highly and specifically expressed on neutrophils. VCAM-1 is one of the effective ligands for the integrin alpha9beta1. This interaction mediates the neutrophile migration on VCAM-1 and extravasation of neutrophils at sites of acute inflammation.
Literature References
PubMed ID
Title
Journal
Year
10209034
The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1
Yednock, T
,
Taooka, Y
,
Sheppard, D
,
Chen, J
J Cell Biol
1999
Participants
Input
Integrin alpha9beta1 [plasma membrane]
(Homo sapiens)
VCAM1 [plasma membrane]
(Homo sapiens)
Output
Integrin alpha9beta1:VCAM-1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Integrin cell surface interactions (Homo sapiens)
Orthologous Events
Interaction of integrin alpha9beta1 with VCAM1 (Bos taurus)
Interaction of integrin alpha9beta1 with VCAM1 (Canis familiaris)
Interaction of integrin alpha9beta1 with VCAM1 (Mus musculus)
Interaction of integrin alpha9beta1 with VCAM1 (Rattus norvegicus)
Interaction of integrin alpha9beta1 with VCAM1 (Sus scrofa)
Authored
Geiger, B (2008-05-07)
Horwitz, AR (2008-05-07)
Reviewed
Humphries, MJ (2008-05-07)
Yamada, KM (2008-05-07)
Hynes, R (2008-05-07)
Created
Garapati, P V (2008-04-18)
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