THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1

Stable Identifier
R-HSA-265429
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The alpha3beta1 integrin is localized in cell-cell junctions of endothelial cells and this integrin is involved in regulating angiogenesis by interacting with thrombospondin-1 (TSP1). Alpha4beta1 integrin binds to the N-terminal pentraxin modules of TSP1 and stimulates chemotaxis and modulates T cell behavior both positively and negatively.
Literature References
PubMed ID Title Journal Year
10982388 Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1

Krutzsch, HC, Chandrasekaran, L, Iruela-Arispe, ML, Al-Barazi, H, He, CZ, Roberts, DD

Mol Biol Cell 2000
11980922 Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior

Krutzsch, HC, Cashel, JA, Mosher, DF, Calzada, MJ, Li, Z, Annis, DS, Sipes, JM, Roberts, DD

J Cell Biol 2002
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