THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1

Stable Identifier
R-HSA-265429
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The alpha3beta1 integrin is localized in cell-cell junctions of endothelial cells and this integrin is involved in regulating angiogenesis by interacting with thrombospondin-1 (TSP1). Alpha4beta1 integrin binds to the N-terminal pentraxin modules of TSP1 and stimulates chemotaxis and modulates T cell behavior both positively and negatively.

Participants
Participant Of
Orthologous Events