THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1

Stable Identifier
R-HSA-265429
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The alpha3beta1 integrin is localized in cell-cell junctions of endothelial cells and this integrin is involved in regulating angiogenesis by interacting with thrombospondin-1 (TSP1). Alpha4beta1 integrin binds to the N-terminal pentraxin modules of TSP1 and stimulates chemotaxis and modulates T cell behavior both positively and negatively.

Literature References
PubMed ID Title Journal Year
11980922 Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior

Li, Z, Calzada, MJ, Sipes, JM, Cashel, JA, Krutzsch, HC, Annis, DS, Mosher, DF, Roberts, DD

J Cell Biol 2002
10982388 Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1

Chandrasekaran, L, He, CZ, Al-Barazi, H, Krutzsch, HC, Iruela-Arispe, ML, Roberts, DD

Mol Biol Cell 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created