Reactome | CACNA1C [plasma membrane]

CACNA1C [plasma membrane]

Stable Identifier

R-HSA-265551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Voltage-gated Calcium Channel Cav1.2-1 (alpha-1 subunit)

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - NCAM signaling for neurite out-growth (Homo sapiens)
      - NCAM1 interactions (Homo sapiens)
        
        NCAM1 interacts with T- and L-type VDCC (Homo sapiens)
        
        NCAM1:T- and L-type VDCC [plasma membrane] (Homo sapiens)
        
        T- and L-type VDCC [plasma membrane] (Homo sapiens)
        
        L-type VDCC [plasma membrane] (Homo sapiens)
        
        CACNA1C [plasma membrane] (Homo sapiens)
        
        T- and L-type VDCC [plasma membrane] (Homo sapiens)
        
        L-type VDCC [plasma membrane] (Homo sapiens)
        
        CACNA1C [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13936 CACNA1C

Gene Names

CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1

Chain

chain:1-2221

Reference Genes

BioGPS Gene:775 CACNA1C

COSMIC (genes):CACNA1C CACNA1C

CTD Gene:775 CACNA1C

dbSNP Gene:775 CACNA1C

ENSEMBL:ENSG00000151067 CACNA1C

HGNC:1390 CACNA1C

KEGG:hsa:775 CACNA1C

Monarch:775 CACNA1C

NCBI Gene:775 CACNA1C

OMIM:114205 CACNA1C

UCSC:Q13936 CACNA1C

Reference Transcript

Other Identifiers

100874369

11733485_a_at

11733486_a_at

11741743_a_at

11741744_x_at

11749085_a_at

11749086_x_at

11750556_a_at

11755927_a_at

16746728

16746801

208020_PM_s_at

208020_s_at

211592_PM_s_at

211592_s_at

238636_PM_at

238636_at

242973_PM_at

242973_at

33623_g_at

3400696

3400726

3400727

3400729

3400731

3400732

3400740

3400741

3400746

3400747

3400748

3400781

3400784

3400791

3400800

3400801

3400806

3400807

3400809

3400826

3400830

3400837

3400840

3400841

3400845

3400846

3400847

3400848

3400849

3400852

3400853

3400854

3400857

3400858

3400859

3400860

3400861

3400862

3400865

3400866

3400867

3400868

3400869

3400871

3400872

3400873

3400874

3400875

3400876

3400877

3400878

3400879

3400880

3400881

3400882

3400883

3400884

3400895

3400898

3400904

3400906

3400907

3400908

3400909

3400910

3400911

3400912

3400913

3400915

3400918

3400920

3400921

3400923

3400924

3400925

3400927

3400928

3400929

3400930

3400931

3400932

3400933

3400936

3400937

3400938

3400939

3400941

3400942

3400943

3400944

3400945

3400946

3400947

3400955

3400956

3401087

3401088

3401089

3401090

3401091

3401095

3449425

38001_at

38002_s_at

55902_at

57485_at

70181_at

76029_at

775

7953040

7953094

A_14_P102314

A_14_P103133

A_14_P113806

A_23_P373028

A_23_P373031

A_33_P3249394

A_33_P3297580

GE498993

GE790167

GE80942

GE852505

GO:0002376

GO:0002520

GO:0005215

GO:0005216

GO:0005245

GO:0005262

GO:0005515

GO:0005516

GO:0005737

GO:0005886

GO:0005891

GO:0006811

GO:0007204

GO:0007507

GO:0008092

GO:0008331

GO:0010881

GO:0014069

GO:0016020

GO:0030018

GO:0030315

GO:0030425

GO:0034702

GO:0035115

GO:0042383

GO:0042995

GO:0043010

GO:0043204

GO:0043226

GO:0045202

GO:0045211

GO:0045762

GO:0045933

GO:0046872

GO:0048856

GO:0051393

GO:0055085

GO:0060402

GO:0061337

GO:0061577

GO:0070588

GO:0086002

GO:0086007

GO:0086012

GO:0086045

GO:0086056

GO:0086064

GO:0086091

GO:0098703

GO:0098839

GO:0098911

GO:0098912

GO:1990454

HMNXSV003006274

HMNXSV003013231

Hs.118262.0.A1_3p_at

Hs.66147.0.A1_3p_at

ILMN_1666775

ILMN_1861819

ILMN_1898404

L04569_at

M92269_f_at

PH_hs_0021168

PH_hs_0023360

PH_hs_0032406

PH_hs_0037427

TC12000021.hg

TC12000024.hg

TC12000025.hg

TC12002177.hg

Z26256_at

Z34822_f_at

g4502524_3p_a_at

g463081_3p_a_at

p25832

p3497

Participates

as a component of

as a member of

L-type VDCC [plasma membrane] (Homo sapiens)

Inferred To

Ghost homologue of CACNA1C [plasma membrane] (Sus scrofa)

Ghost homologue of CACNA1C [plasma membrane] (Xenopus tropicalis)

CACNA1C [plasma membrane] (Bos taurus)

CACNA1C [plasma membrane] (Caenorhabditis elegans)

CACNA1C [plasma membrane] (Canis familiaris)

CACNA1C [plasma membrane] (Drosophila melanogaster)

CACNA1C [plasma membrane] (Gallus gallus)

CACNA1C [plasma membrane] (Mus musculus)

CACNA1C [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001161095.1, NP_001161097.1, NP_000710.5, NP_001161096.2, NP_955630.3, NP_001123316.1, NP_001123304.1, NP_001123302.2, NP_001123315.1, NP_001123299.1, NP_001123318.1, NP_001123306.1, NP_001123305.1, NP_001123309.1, NP_001123308.1, NP_001123307.1, NP_001123312.1, NP_001123310.1, NP_001123311.1, NP_001123303.1, NP_001123301.1, NP_001123314.1, NP_001123313.1

ZINC - World Drugs

CAC1C_HUMAN

Guide to Pharmacology - Targets

529

OpenTargets

ENSG00000151067

ENSEMBL

ENST00000399629, ENST00000399649, ENSP00000494420, ENST00000399603, ENSP00000518305, ENSP00000266376, ENST00000399644, ENSP00000518307, ENSP00000382552, ENSP00000493781, ENST00000645965, ENSP00000382530, ENST00000710487, ENSP00000494095, ENST00000645584, ENSP00000494058, ENSP00000382563, ENSP00000382510, ENSP00000341092, ENSP00000493890, ENSP00000494999, ENST00000344100, ENST00000644369, ENST00000399595, ENSP00000496458, ENST00000710479, ENST00000682686, ENSP00000382557, ENST00000643701, ENST00000347598, ENSP00000382512, ENSP00000385724, ENSP00000494765, ENSP00000382546, ENSP00000496749, ENST00000683482, ENST00000643038, ENSP00000382537, ENSP00000382515, ENST00000399621, ENST00000644691, ENST00000647062, ENST00000399637, ENSP00000382504, ENST00000399641, ENST00000643858, ENSP00000382547, ENSP00000494782, ENST00000399606, ENSP00000493573, ENSP00000507169, ENSP00000496681, ENST00000399601, ENST00000647327, ENST00000644235, ENST00000647521, ENST00000644891, ENSP00000507309, ENST00000646257, ENSP00000495576, ENSP00000496049, ENSP00000495080, ENST00000644048, ENST00000644660, ENST00000402845, ENST00000643138, ENST00000642583, ENSP00000494018, ENST00000399591, ENSP00000382506, ENSP00000495678, ENSP00000382500, ENSP00000382549, ENST00000399638, ENST00000399655, ENST00000399597

ZINC - FDA approved

CAC1C_HUMAN

ZINC - Substances

CAC1C_HUMAN

ZINC - Biogenic

CAC1C_HUMAN

ZINC target

Q13936

PRO

Q13936

GlyGen

Q13936

PDB

5V2Q, 2BE6, 8WE8, 8EOI, 8EOG, 6DAD, 6DAF, 8WE9, 8WE6, 2LQC, 3G43, 8WEA, 6DAE, 8WE7, 3OXQ, 8FD7, 6U39, 6U3D, 6U3B, 7L8V, 6U3A, 8FHS, 5V2P, 6C0A, 2F3Y, 2F3Z, 1T0J

ZINC - Investigational

CAC1C_HUMAN

ZINC - Metabolites

CAC1C_HUMAN

HPA

ENSG00000151067-CACNA1C

Pharos - Targets

Q13936

Orphanet

CACNA1C

ZINC - Predictions - Purchasable

CAC1C_HUMAN

HMDB Protein

HMDBP02220

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.632	4
UniProt:Q9BXP5 SRRT	1	SRRT [nucleoplasm] (R-HSA-6814858)	0.547	2
UniProt:Q9NZU7 CABP1	1	CABP1 [plasma membrane] (R-HSA-9672322)	0.524	4
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.508	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.499	2
UniProt:P01024 C3	20	C3d fragment [extracellular region] (R-HSA-198999) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [secretory granule lumen] (R-HSA-6801014) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3a-desArg [extracellular region] (R-HSA-8852808) C3dg [plasma membrane] (R-HSA-3266505) C3d [plasma membrane] (R-HSA-8853248) C3f [extracellular region] (R-HSA-976779) C3 beta chain [plasma membrane] (R-HSA-977593) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3 alpha chain [extracellular region] (R-HSA-166820) C3b alpha' [extracellular region] (R-HSA-166830) C3 beta chain [extracellular region] (R-HSA-166821)	0.499	2
UniProt:Q06413 MEF2C	3	MEF2C [nucleoplasm] (R-HSA-199938) p-S396-MEF2C [nucleoplasm] (R-HSA-199942) p-T293,T300,S387-MEF2C [nucleoplasm] (R-HSA-448838)	0.499	4
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.499	2

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