GGT1, 5 dimers hydrolyse LTC4 to LTD4

Stable Identifier
R-HSA-266046
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4
Locations in the PathwayBrowser
Summation

The reversible conversion of leukotriene C4 (LTC4) to leukotriene D4 (LTD4) is catalysed by gamma-glutamyl transferases 1 (GGT1) and 5 (GGT5). GGTs are present on the outer surface of plasma membranes and are a heterodimer of a heavy and a light chain. Its action involves the hydrolysis of the gamma-glutamyl peptide bond of glutathione and glutathione conjugates, releasing glutamate. In this example, LTC4 is a glutathione conjugate that is hydrolysed to LTD4 (Anderson et al. 1982, Wickham et al. 2011).

Literature References
PubMed ID Title Journal Year
21447318 Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes

Wickham, S, West, MB, Cook, PF, Hanigan, MH

Anal Biochem 2011
6122208 Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids

Anderson, ME, Allison, RD, Meister, A

Proc Natl Acad Sci U S A 1982
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione hydrolase activity of GGT1, 5 dimers [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed