LTA4 is converted to LTC4 by LTC4S

Stable Identifier
R-HSA-266050
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
LTA4 conjugates with glutathione to form LTC4
Locations in the PathwayBrowser
Summation

Leukotriene A4 conjugates with reduced glutathione (GSH) to produce leukotriene C4 (LTC4). This conjugation is mediated by the homodimeric, perinuclear membrane-bound enzyme leukotriene C4 synthase (LTC4S) (Lam et al. 1994, Welsch et al. 1994). LTC4S differs from cytosolic and microsomal GSH-S-transferases by having a very narrow substrate specificity and the inability to conjugate xenobiotics.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
leukotriene-C4 synthase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea