5S-HpETE is dehydrated to LTA4 by ALOX5

Stable Identifier
R-HSA-266051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Dehydration of 5-HpETE to leukotriene A4
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In the second step of the formation of leukotriene A4 (LTA4) from arachidonic acid, arachidonate 5-lipoxygenase (ALOX5) converts 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) to an allylic epoxide, leukotriene A4 (LTA4) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986).

Literature References
PubMed ID Title Journal Year
3006030 Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities

Rouzer, CA, Matsumoto, T, Samuelsson, B

Proc Natl Acad Sci U S A 1986
3118366 Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase

Rouzer, CA, Samuelsson, B

Proc Natl Acad Sci U S A 1987
3164719 Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells

Rouzer, CA, Rands, E, Kargman, S, Jones, RE, Register, RB, Dixon, RA

J Biol Chem 1988
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 5-lipoxygenase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created