Reactome: A Curated Pathway Database

5S-HpETE is dehydrated to LTA4 by ALOX5

Stable Identifier
R-HSA-266051
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Dehydration of 5-HpETE to leukotriene A4
Locations in the PathwayBrowser
Summation

In the second step of the formation of leukotriene A4 (LTA4) from arachidonic acid, arachidonate 5-lipoxygenase (ALOX5) converts 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) to an allylic epoxide, leukotriene A4 (LTA4) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
arachidonate 5-lipoxygenase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope] ALOX5:ALOX5AP:LTC4S [nuclear envelope] arachidonate 5-lipoxygenase activity (0004051)
Orthologous Events
Cross References
Rhea