LTA4 is hydolysed to LTB4 by LTA4H

Stable Identifier
R-HSA-266072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
LTA4 is hydrolyzed to LTB4
Locations in the PathwayBrowser
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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that catalyzes the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) to the dihydroxy acid leukotriene B4 (LTB4) (Radmark et al. 1984, McGee & Fitzpatrick 1985).

Literature References
PubMed ID Title Journal Year
2995393 Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes

McGee, J, Fitzpatrick, F

J Biol Chem 1985
6490615 Leukotriene A4 hydrolase in human leukocytes. Purification and properties

Rådmark, O, Shimizu, T, Jörnvall, H, Samuelsson, B

J Biol Chem 1984
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
leukotriene-A4 hydrolase activity of LTA4H:Zn2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created