Reactome | Association of HMGB1/HMGB2 with chromatin

Association of HMGB1/HMGB2 with chromatin

Stable Identifier

R-HSA-266204

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Association of HMGB1/HMGB2 with chromatin

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The major HMG-box-containing chromatin proteins HMGB1 and HMGB2 stimulate DNA cleavage by DFF40/CAD (Liu et al., 1998; Toh et al., 1998; Widlak et al., 2000). Changes in DNA conformation following HMG-box binding makes the substrate more accessible to cleavage by DFF40/CAD nuclease and thus may contribute to preferential linker DNA cleavage during apoptosis (Kalinowska-Herok and Widlak., 2008).

Literature References

PubMed ID	Title	Journal	Year
18239742	High mobility group proteins stimulate DNA cleavage by apoptotic endonuclease DFF40/CAD due to HMG-box interactions with DNA Kalinowska-Herok, M, Wid?ak, P	Acta Biochim Pol	2008