Reactome | HMGB1 [nucleoplasm]

HMGB1 [nucleoplasm]

Stable Identifier

R-HSA-266221

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

High mobility group protein B1, Amphoterin

Locations in the PathwayBrowser for interactor UniProt:O00206 TLR4

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External Reference Information

External Reference

UniProt:P09429 HMGB1

Gene Names

HMGB1, HMG1

Chain

chain:1-215

Reference Genes

BioGPS Gene:3146 HMGB1

COSMIC (genes):HMGB1 HMGB1

CTD Gene:3146 HMGB1

dbSNP Gene:3146 HMGB1

ENSEMBL:ENSG00000189403 HMGB1

ENSEMBL_homo_sapiens_GENE:ENSG00000189403.15 HMGB1

HGNC:4983 HMGB1

KEGG Gene (Homo sapiens):3146 HMGB1

Monarch:3146 HMGB1

NCBI Gene:3146 HMGB1

OMIM:163905 HMGB1

UCSC:P09429 HMGB1

Reference Transcript

Other Identifiers

11739025_a_at

11739026_x_at

11745717_x_at

11755681_x_at

11757785_x_at

11758181_s_at

17123388

17123390

200679_PM_x_at

200679_x_at

200680_3p_x_at

200680_PM_x_at

200680_x_at

214938_PM_x_at

214938_x_at

224731_PM_at

224731_at

224734_PM_at

224734_at

2586472

2613807

2613808

3146

3508068

3508069

3508070

3508071

3508072

3508073

3508074

3508075

3508076

3508077

3508084

3508085

3508086

3508087

3508089

3508091

3508092

3508094

3508095

3508121

3508122

3508123

3508124

3508125

3631589

3631590

3631593

3631595

3638277

3911151

3941057

3941058

3941059

59135_at

65806_at

67687_at

7970858

8078248

88847_at

A_23_P99980

A_23_P99985

A_32_P134580

D63874_at

GE85813

GE891138

GO:0000122

GO:0000400

GO:0000405

GO:0000793

GO:0000976

GO:0001530

GO:0001773

GO:0001786

GO:0002218

GO:0002250

GO:0002376

GO:0002407

GO:0002437

GO:0002643

GO:0002840

GO:0003677

GO:0003684

GO:0003690

GO:0003697

GO:0003713

GO:0003714

GO:0003723

GO:0003824

GO:0005125

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005768

GO:0005783

GO:0005793

GO:0005886

GO:0006265

GO:0006281

GO:0006303

GO:0006310

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006914

GO:0006935

GO:0006954

GO:0006974

GO:0007155

GO:0007165

GO:0007204

GO:0008289

GO:0008301

GO:0009986

GO:0010508

GO:0012501

GO:0016020

GO:0016192

GO:0016829

GO:0017053

GO:0017055

GO:0019958

GO:0023052

GO:0030154

GO:0031175

GO:0031410

GO:0031507

GO:0032072

GO:0032392

GO:0032425

GO:0032689

GO:0032732

GO:0032733

GO:0032735

GO:0032755

GO:0032757

GO:0032760

GO:0033151

GO:0034165

GO:0034774

GO:0035711

GO:0035868

GO:0042056

GO:0042104

GO:0043065

GO:0043226

GO:0043277

GO:0043280

GO:0043371

GO:0043388

GO:0043410

GO:0043536

GO:0043537

GO:0045063

GO:0045087

GO:0045944

GO:0046330

GO:0046598

GO:0048018

GO:0048856

GO:0048870

GO:0050786

GO:0050918

GO:0051106

GO:0061629

GO:0065003

GO:0070182

GO:0070374

GO:0071222

GO:0090026

GO:0097100

GO:0097350

GO:0098542

GO:0098772

GO:0140110

GO:0140297

GO:1904813

GO:1905564

GO:2000343

GO:2000426

GO:2001200

HMNXSV003052837

Hs.274472.0.S1_3p_x_at

Hs.274472.2.A1_3p_x_at

Hs.324278.0.A1_3p_at

Hs.324278.0.A2_3p_at

ILMN_1791466

ILMN_2231242

PH_hs_0030197

PH_hs_0036941

TC03000120.hg

TC03002251.hg

TC03002252.hg

TC13001407.hg

g4504424_3p_a_at

Participates

as a member of

HMGB1/HMGB2 [nucleoplasm] (Homo sapiens)

as an input of

HMGB1 release from cells (Homo sapiens)

Other forms of this molecule

HMGB1 [secretory granule lumen]

HMGB1 [ficolin-1-rich granule lumen]

HMGB1 [extracellular region]

HC23,45-HMGB1 [extracellular region]

Inferred To

Homologues of HMGB1 [nucleoplasm] (Rattus norvegicus)

Homologues of HMGB1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of HMGB1 [nucleoplasm] (Schizosaccharomyces pombe)

NHP10 [nucleoplasm] (Saccharomyces cerevisiae)

NHP6A [nucleoplasm] (Saccharomyces cerevisiae)

cmb1 [nucleoplasm] (Schizosaccharomyces pombe)

ABF2 [nucleoplasm] (Saccharomyces cerevisiae)

IXR1 [nucleoplasm] (Saccharomyces cerevisiae)

hmgb1a [nucleoplasm] (Danio rerio)

HMO1 [nucleoplasm] (Saccharomyces cerevisiae)

nhp6 [nucleoplasm] (Dictyostelium discoideum)

nhp6 [nucleoplasm] (Schizosaccharomyces pombe)

Dsp1 [nucleoplasm] (Drosophila melanogaster)

Hmgb1l2 [nucleoplasm] (Rattus norvegicus)

hmg-1.2 [nucleoplasm] (Caenorhabditis elegans)

Hmgb1l1 [nucleoplasm] (Rattus norvegicus)

HMGB1 [nucleoplasm] (Bos taurus)

HMGB1 [nucleoplasm] (Canis familiaris)

HMGB1 [nucleoplasm] (Gallus gallus)

HMGB1 [nucleoplasm] (Mus musculus)

HMGB1 [nucleoplasm] (Plasmodium falciparum)

HMGB1 [nucleoplasm] (Rattus norvegicus)

HMGB1 [nucleoplasm] (Schizosaccharomyces pombe)

hmgb1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001300822.1, NP_001300821.1, NP_002119.1

Guide to Pharmacology - Targets

3279

OpenTargets

ENSG00000189403

HPA

ENSG00000189403-HMGB1

GeneCards

P09429

Ensembl

ENSP00000343040, ENSG00000189403, ENST00000339872, ENSP00000382417, ENST00000399494, ENSP00000345347, ENST00000405805, ENSP00000384678, ENST00000341423

PRO

P09429

Pharos - Targets

P09429

HMDB Protein

HMDBP13794

PDB

6CIJ, 6CG0, 6OEM, 6CIL, 8I9M, 6OEN, 2YRQ, 2LY4, 6CIM, 6CIK, 2RTU, 6OEO

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.74	9
UniProt:P08729 KRT7	1	KRT7 [cytosol] (R-HSA-6809642)	0.736	6
UniProt:Q96T23 RSF1	1	RSF1 [nucleoplasm] (R-HSA-606345)	0.667	3
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.613	3
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.613	3
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.604	3
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.556	3
UniProt:O95273 CCDB1			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q96PU4 UHRF2	1	UHRF2 [nucleoplasm] (R-HSA-976050)	0.553	2
UniProt:P02795 MT2A	1	MT2A [cytosol] (R-HSA-1031707)	0.553	2
UniProt:Q96B54 ZN428			0.553	3
UniProt:P47914 RPL29	1	RPL29 [cytosol] (R-HSA-72446)	0.553	2
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.527	2
UniProt:Q6S8J3 POTEE	1	POTEE [cytosol] (R-HSA-9715126)	0.527	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.518	13
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.499	2
UniProt:P43246 MSH2	3	MSH2 R406* [nucleoplasm] (R-HSA-5575594) MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243)	0.499	2
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.488	2
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.483	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.482	2
UniProt:P25398 RPS12	2	RPS12 [nucleoplasm] (R-HSA-6798715) RPS12 [cytosol] (R-HSA-72329)	0.482	2
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.482	2

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