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HMGB1 [nucleoplasm]
Stable Identifier
R-HSA-266221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
High mobility group protein B1, Amphoterin
Locations in the PathwayBrowser for interactor UniProt:P84103 SRSF3
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
HMGB1 release from cells (Homo sapiens)
HMGB1 [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
HMGB1 release from cells (Homo sapiens)
HMGB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09429 HMGB1
Gene Names
HMGB1, HMG1
Chain
chain:1-215
Reference Genes
BioGPS Gene:3146 HMGB1
COSMIC (genes):HMGB1 HMGB1
CTD Gene:3146 HMGB1
dbSNP Gene:3146 HMGB1
ENSEMBL:ENSG00000189403 HMGB1
HGNC:4983 HMGB1
KEGG:hsa:3146 HMGB1
Monarch:3146 HMGB1
NCBI Gene:3146 HMGB1
OMIM:163905 HMGB1
UCSC:P09429 HMGB1
Reference Transcript
RefSeq:NM_001313893.1 HMGB1
RefSeq:NM_001313892.1 HMGB1
RefSeq:NM_002128.5 HMGB1
Other Identifiers
11739025_a_at
11739026_x_at
11745717_x_at
11755681_x_at
11757785_x_at
11758181_s_at
11760158_at
17123388
17123390
200679_PM_x_at
200679_x_at
200680_3p_x_at
200680_PM_x_at
200680_x_at
214938_PM_x_at
214938_x_at
224731_PM_at
224731_at
224734_PM_at
224734_at
2586472
2613807
2613808
3146
3508068
3508069
3508070
3508071
3508072
3508073
3508074
3508075
3508076
3508077
3508078
3508079
3508080
3508081
3508082
3508083
3508084
3508085
3508086
3508087
3508088
3508089
3508090
3508091
3508092
3508093
3508094
3508095
3508121
3508122
3508123
3508124
3508125
3631589
3631590
3631593
3631595
3638277
3911151
3941057
3941058
3941059
59135_at
65806_at
67687_at
7970858
8078248
88847_at
A_23_P99980
A_23_P99985
A_32_P134580
D63874_at
GE85813
GE86118
GE891138
GO:0000122
GO:0000400
GO:0000405
GO:0000793
GO:0000976
GO:0001530
GO:0001773
GO:0001786
GO:0002218
GO:0002250
GO:0002376
GO:0002407
GO:0002437
GO:0002643
GO:0002840
GO:0003677
GO:0003684
GO:0003690
GO:0003697
GO:0003713
GO:0003714
GO:0003723
GO:0003824
GO:0005125
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005768
GO:0005783
GO:0005793
GO:0005886
GO:0006265
GO:0006281
GO:0006303
GO:0006310
GO:0006325
GO:0006355
GO:0006357
GO:0006914
GO:0006935
GO:0006954
GO:0007165
GO:0007204
GO:0008289
GO:0008301
GO:0009986
GO:0010508
GO:0016192
GO:0016829
GO:0017053
GO:0017055
GO:0019958
GO:0030154
GO:0031175
GO:0031410
GO:0031507
GO:0032072
GO:0032392
GO:0032425
GO:0032689
GO:0032732
GO:0032733
GO:0032735
GO:0032755
GO:0032757
GO:0032760
GO:0033151
GO:0034165
GO:0034774
GO:0035711
GO:0035868
GO:0042056
GO:0042104
GO:0043065
GO:0043226
GO:0043277
GO:0043280
GO:0043371
GO:0043388
GO:0043410
GO:0043536
GO:0043537
GO:0045063
GO:0045087
GO:0045944
GO:0046330
GO:0046598
GO:0048018
GO:0048870
GO:0050786
GO:0050918
GO:0051106
GO:0060090
GO:0061629
GO:0070182
GO:0070374
GO:0071222
GO:0090026
GO:0097100
GO:0097350
GO:0098542
GO:0098772
GO:0140110
GO:0140297
GO:1904813
GO:1905564
GO:2000343
GO:2000426
GO:2001200
HMNXSV003052837
Hs.274472.0.S1_3p_x_at
Hs.274472.2.A1_3p_x_at
Hs.324278.0.A1_3p_at
Hs.324278.0.A2_3p_at
ILMN_1791466
ILMN_2231242
PH_hs_0030197
PH_hs_0036941
TC03000120.hg
TC03002251.hg
TC03002252.hg
TC13001407.hg
g4504424_3p_a_at
Participates
as a member of
HMGB1/HMGB2 [nucleoplasm] (Homo sapiens)
as an input of
HMGB1 release from cells (Homo sapiens)
Other forms of this molecule
HC23,45-HMGB1 [extracellular region]
HMGB1 [extracellular region]
HMGB1 [secretory granule lumen]
HMGB1 [ficolin-1-rich granule lumen]
Inferred To
Homologues of HMGB1 [nucleoplasm]
(Rattus norvegicus)
Homologues of HMGB1 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of HMGB1 [nucleoplasm]
(Schizosaccharomyces pombe)
NHP10 [nucleoplasm]
(Saccharomyces cerevisiae)
NHP6A [nucleoplasm]
(Saccharomyces cerevisiae)
LOC134483981 [nucleoplasm]
(Rattus norvegicus)
cmb1 [nucleoplasm]
(Schizosaccharomyces pombe)
ABF2 [nucleoplasm]
(Saccharomyces cerevisiae)
IXR1 [nucleoplasm]
(Saccharomyces cerevisiae)
hmgb1a [nucleoplasm]
(Danio rerio)
HMO1 [nucleoplasm]
(Saccharomyces cerevisiae)
nhp6 [nucleoplasm]
(Dictyostelium discoideum)
nhp6 [nucleoplasm]
(Schizosaccharomyces pombe)
Dsp1 [nucleoplasm]
(Drosophila melanogaster)
Hmgb1l2 [nucleoplasm]
(Rattus norvegicus)
hmg-1.2 [nucleoplasm]
(Caenorhabditis elegans)
Hmgb1l1 [nucleoplasm]
(Rattus norvegicus)
HMGB1 [nucleoplasm]
(Bos taurus)
HMGB1 [nucleoplasm]
(Canis familiaris)
HMGB1 [nucleoplasm]
(Gallus gallus)
HMGB1 [nucleoplasm]
(Mus musculus)
HMGB1 [nucleoplasm]
(Plasmodium falciparum)
HMGB1 [nucleoplasm]
(Rattus norvegicus)
HMGB1 [nucleoplasm]
(Schizosaccharomyces pombe)
hmgb1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002119.1
,
NP_001300822.1
,
NP_001300821.1
Guide to Pharmacology - Targets
3279
OpenTargets
ENSG00000189403
ENSEMBL
ENST00000405805
,
ENSP00000345347
,
ENSP00000384678
,
ENST00000341423
,
ENST00000399494
,
ENST00000339872
,
ENSP00000343040
,
ENSP00000382417
HPA
ENSG00000189403-HMGB1
PRO
P09429
Pharos - Targets
P09429
GlyGen
P09429
HMDB Protein
HMDBP13794
PDB
8I9M
,
2YRQ
,
6CG0
,
6OEN
,
6OEO
,
6CIL
,
6OEM
,
6CIM
,
2RTU
,
6CIK
,
6CIJ
,
2LY4
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.74
9
UniProt:P08729 KRT7
1
KRT7 [cytosol]
(R-HSA-6809642)
0.736
6
UniProt:Q96T23 RSF1
1
RSF1 [nucleoplasm]
(R-HSA-606345)
0.667
3
UniProt:P84103 SRSF3
1
SRSF3 [nucleoplasm]
(R-HSA-72035)
0.613
3
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.613
3
UniProt:O00206 TLR4
2
TLR4 [endosome membrane]
(R-HSA-2201285)
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
0.604
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:O95273 CCDB1
0.556
3
UniProt:Q6RW13 AGTRAP
2
AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]
(R-HSA-6802262)
AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]
(R-HSA-6802511)
0.556
3
UniProt:P02795 MT2A
1
MT2A [cytosol]
(R-HSA-1031707)
0.553
2
UniProt:P47914 RPL29
1
RPL29 [cytosol]
(R-HSA-72446)
0.553
2
UniProt:Q96B54 ZN428
0.553
3
UniProt:Q96PU4 UHRF2
1
UHRF2 [nucleoplasm]
(R-HSA-976050)
0.553
2
UniProt:Q6S8J3 POTEE
1
POTEE [cytosol]
(R-HSA-9715126)
0.527
2
UniProt:P23497 SP100
3
polySUMO2-K297-SP100 [nucleoplasm]
(R-HSA-3000454)
monoSUMO1-K297-SP100 [nucleoplasm]
(R-HSA-3000382)
SP100 [nucleoplasm]
(R-HSA-1031705)
0.527
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.518
13
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.499
2
UniProt:P43246 MSH2
3
MSH2 [nucleoplasm]
(R-HSA-5357525)
MSH2 GLN601TER [nucleoplasm]
(R-HSA-5577243)
MSH2 R406* [nucleoplasm]
(R-HSA-5575594)
0.499
2
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cilium]
(R-HSA-5632507)
CSNK1A1 [cytosol]
(R-HSA-195263)
0.488
2
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.483
2
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.482
2
UniProt:P60866 RPS20
2
RPS20 [cytosol]
(R-HSA-72349)
RPS20 [nucleoplasm]
(R-HSA-6798727)
0.482
2
UniProt:P25398 RPS12
2
RPS12 [cytosol]
(R-HSA-72329)
RPS12 [nucleoplasm]
(R-HSA-6798715)
0.482
2
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