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LCAT + spherical HDL <=> LCAT:spherical HDL complex
Stable Identifier
R-HSA-266315
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein remodeling (Homo sapiens)
HDL remodeling (Homo sapiens)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
LCAT (lecithin-cholesterol acyltransferase) associates strongly but reversibly with spherical HDL particles (Jonas 2000).
Literature References
PubMed ID
Title
Journal
Year
9829992
Structural and functional properties of two mutants of lecithin-cholesterol acyltransferase (T123I and N228K)
Shieh, JJ
,
Grabbe, E
,
Jin, L
,
Adimoolam, S
,
Jonas, A
J Biol Chem
1998
Participants
Input
LCAT [extracellular region]
(Homo sapiens)
spherical HDL [extracellular region]
(Homo sapiens)
Output
LCAT:spherical HDL complex [extracellular region]
(Homo sapiens)
Participates
as an event of
HDL remodeling (Homo sapiens)
Event Information
Reverse Reaction
LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)
Orthologous Events
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Bos taurus)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Gallus gallus)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Mus musculus)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Rattus norvegicus)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Sus scrofa)
Authored
D'Eustachio, P (2008-05-12)
Reviewed
Jassal, B (2008-06-13)
Created
D'Eustachio, P (2008-05-05)
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