JAK2 Phosphoryates STAT3 in Response to Leptin

Stable Identifier
R-HSA-2671850
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated JAK2 in the LEP:LEPR:JAK2:STAT3 complex phosphorylates STAT3 at tyrosine-705 (Bjorbaek et al. 1997).
Literature References
PubMed ID Title Journal Year
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor

da Silva, B, Uotani, S, Flier, JS, Bjørbaek, C

J. Biol. Chem. 1997
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of LEP:p-LEPR:p-JAK2:STAT3 [plasma membrane]

Inferred From
Authored
Reviewed
Created
Cite Us!