Stimuli-sensing channels

Stable Identifier
R-HSA-2672351
Type
Pathway
Species
Homo sapiens
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Ion channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et al. 2012, Deval et al. 2010) and the transient receptor potential channels (TRPCs) (Takahashi et al. 2012, Numata et al. 2011 in "TRP Channels" Zhu, MX editor, CRC Press, 2011, Ramsey et al. 2006, Montell 2005). Many channels are sensitive to changes in calcium (Ca2+) levels, both inside and outside the cell. Examples are protein tweety homologs 2 and 3 (TTYH2, 3) (Suzuki 2006), bestrophins 1-4 (BEST1-4) (Sun et al. 2002, Tsunenari et al. 2003, Kunzelmann et al. 2009, Hartzell et al. 2008) and ryanodine receptor tetramers (RYRs) (Beard et al. 2009).

Literature References
PubMed ID Title Journal Year
16219661 The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels

Suzuki, M

Exp. Physiol. 2006
20807551 Acid-sensing ion channels (ASICs): pharmacology and implication in pain

Deval, E, Gasull, X, Noël, J, Salinas, M, Baron, A, Diochot, S, Lingueglia, E

Pharmacol. Ther. 2010
21932071 Acidosis, acid-sensing ion channels, and neuronal cell death

Wang, YZ, Xu, TL

Mol. Neurobiol. 2011
12907679 Structure-function analysis of the bestrophin family of anion channels

Tsunenari, T, Sun, H, Williams, J, Cahill, H, Smallwood, P, Yau, KW, Nathans, J

J. Biol. Chem. 2003
18391176 Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies

Hartzell, HC, Qu, Z, Yu, K, Xiao, Q, Chien, LT

Physiol. Rev. 2008
  TRP Channels

Xhu, MX

  2011
11904445 The vitelliform macular dystrophy protein defines a new family of chloride channels

Sun, H, Tsunenari, T, Yau, KW, Nathans, J

Proc. Natl. Acad. Sci. U.S.A. 2002
15728426 The TRP superfamily of cation channels

Montell, C

Sci. STKE 2005
16460286 An introduction to TRP channels

Ramsey, IS, Delling, M, Clapham, DE

Annu. Rev. Physiol. 2006
19783045 Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions

Kunzelmann, K, Kongsuphol, P, Aldehni, F, Tian, Y, Ousingsawat, J, Warth, R, Schreiber, R

Cell Calcium 2009
19278523 Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen

Beard, NA, Wei, L, Dulhunty, AF

Clin. Exp. Pharmacol. Physiol. 2009
22277752 ENaCs and ASICs as therapeutic targets

Qadri, YJ, Rooj, AK, Fuller, CM

Am. J. Physiol., Cell Physiol. 2012
22934072 TRP channels: sensors and transducers of gasotransmitter signals

Takahashi, N, Kozai, D, Mori, Y

Front Physiol 2012
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