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EPHA4 [plasma membrane]
Stable Identifier
R-HSA-2682325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin type-A receptor 4 ecNumber2.7.10.1/ecNumber, EPHA4_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P19086 GNAZ
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
Expression of EPHA4 in presomitic mesoderm (Homo sapiens)
EPHA4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54764 EPHA4
Gene Names
EPHA4, HEK8, SEK, TYRO1
Chain
signal peptide:1-19, chain:20-986
Reference Genes
BioGPS Gene:2043 EPHA4
COSMIC (genes):EPHA4 EPHA4
CTD Gene:2043 EPHA4
dbSNP Gene:2043 EPHA4
ENSEMBL:ENSG00000116106 EPHA4
ENSEMBL_homo_sapiens_GENE:ENSG00000116106.12 EPHA4
HGNC:3388 EPHA4
KEGG Gene (Homo sapiens):2043 EPHA4
Monarch:2043 EPHA4
NCBI Gene:2043 EPHA4
OMIM:602188 EPHA4
UCSC:P54764 EPHA4
Reference Transcript
RefSeq:NM_001304536.1 EPHA4
RefSeq:NM_004438.4 EPHA4
RefSeq:NM_001304537.1 EPHA4
Other Identifiers
11723440_a_at
11723441_a_at
11723442_at
11723443_at
1606_at
16908897
2043
206114_PM_at
206114_at
227449_PM_at
227449_at
228948_PM_at
228948_at
229374_PM_at
229374_at
238671_PM_at
238671_at
2600690
2600691
2600692
2600693
2600694
2600699
2600700
2600701
2600703
2600704
2600708
2600711
2600713
2600721
2600723
2600725
2600728
2600730
2600731
2600743
2600746
2600767
2600769
2600773
2600774
2600776
53937_at
62566_at
63932_at
8059279
A_23_P108501
A_23_P119899
A_24_P274219
GE79501
GE80223
GO:0000166
GO:0001540
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005004
GO:0005005
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005741
GO:0005768
GO:0005769
GO:0005886
GO:0005912
GO:0006468
GO:0007155
GO:0007162
GO:0007169
GO:0007399
GO:0007411
GO:0007628
GO:0008045
GO:0008284
GO:0008347
GO:0009986
GO:0010719
GO:0010977
GO:0014069
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017148
GO:0018108
GO:0021957
GO:0023052
GO:0030154
GO:0030163
GO:0030175
GO:0030335
GO:0030336
GO:0030424
GO:0030425
GO:0031410
GO:0031594
GO:0031901
GO:0034330
GO:0034332
GO:0036211
GO:0042731
GO:0042734
GO:0042802
GO:0042995
GO:0043087
GO:0043197
GO:0043198
GO:0043204
GO:0043226
GO:0043679
GO:0044295
GO:0044297
GO:0045202
GO:0045211
GO:0045785
GO:0046777
GO:0046875
GO:0048013
GO:0048681
GO:0048710
GO:0048856
GO:0048870
GO:0050770
GO:0050775
GO:0050821
GO:0060089
GO:0061001
GO:0061098
GO:0070161
GO:0070373
GO:0072178
GO:0090102
GO:0097155
GO:0097156
GO:0097161
GO:0097485
GO:0098685
GO:0098839
GO:0098883
GO:0098978
GO:0106030
GO:0140096
GO:1900038
GO:1900272
GO:1902004
GO:1902961
GO:1903051
GO:1904646
GO:1905244
GO:1905806
GO:1990782
GO:2001108
HMNXSV003043201
Hs.173596.0.A1_3p_at
Hs.244624.0.A1_3p_at
Hs.244624.1.A1_3p_at
Hs.314784.0.A1_3p_at
ILMN_1672022
L36645_at
PH_hs_0004230
PH_hs_0013017
TC02002808.hg
g4758279_3p_at
Participates
as a member of
EPHAs [plasma membrane] (Homo sapiens)
as an output of
Expression of EPHA4 in presomitic mesoderm (Homo sapiens)
Other forms of this molecule
p-Y596,Y602-EPHA4 [plasma membrane]
Inferred To
Epha4 [plasma membrane]
(Mus musculus)
EPHA4 [plasma membrane]
(Bos taurus)
EPHA4 [plasma membrane]
(Canis familiaris)
EPHA4 [plasma membrane]
(Gallus gallus)
EPHA4 [plasma membrane]
(Rattus norvegicus)
EPHA4 [plasma membrane]
(Sus scrofa)
EPHA4 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004429.1
,
NP_001291465.1
,
NP_001291466.1
ZINC - World Drugs
EPHA4_HUMAN
Guide to Pharmacology - Targets
1824
OpenTargets
ENSG00000116106
ZINC - FDA approved
EPHA4_HUMAN
ZINC - Substances
EPHA4_HUMAN
ZINC - Biogenic
EPHA4_HUMAN
ZINC target
P54764
PRO
P54764
PDB
4W4Z
,
2WO2
,
2WO3
,
4BKF
,
4BK4
,
4M4R
,
4M4P
,
3GXU
,
4W50
,
5JR2
,
4BKA
,
3CKH
,
7OFV
,
2WO1
,
2LW8
,
4BK5
ZINC - Investigational
EPHA4_HUMAN
HPA
ENSG00000116106-EPHA4
GeneCards
P54764
Ensembl
ENSG00000116106
,
ENST00000281821
,
ENSP00000386829
,
ENST00000409938
,
ENSP00000281821
Pharos - Targets
P54764
Orphanet
23741
ZINC - Predictions - Purchasable
EPHA4_HUMAN
HMDB Protein
HMDBP01429
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52803 EFNA5
3
EFNA5 (21-?) N-ter [extracellular region]
(R-HSA-3928456)
EFNA5 (?-203) C-ter [plasma membrane]
(R-HSA-3928431)
EFNA5 [plasma membrane]
(R-HSA-2682331)
0.713
4
UniProt:Q15768 EFNB3
2
p-Y318,Y323,Y337-EFNB3 [plasma membrane]
(R-HSA-3928388)
EFNB3 [plasma membrane]
(R-HSA-2682319)
0.688
3
UniProt:P52799 EFNB2
2
p-Y311,Y316,Y330-EFNB2 [plasma membrane]
(R-HSA-3928387)
EFNB2 [plasma membrane]
(R-HSA-2682330)
0.65
4
UniProt:O43921 EFNA2
3
EFNA2 (25-?) N-ter [extracellular region]
(R-HSA-3928464)
EFNA2 (?-188) C-ter [plasma membrane]
(R-HSA-3928471)
EFNA2 [plasma membrane]
(R-HSA-2682320)
0.65
4
UniProt:Q9BVA1 TUBB2B
6
TUBB2B folding intermediate [cytosol]
(R-HSA-392796)
TUBB2B unfolded [cytosol]
(R-HSA-392768)
Polyglycyl-TUBB2B [cytosol]
(R-HSA-8867393)
Polyglutamyl-TUBB2B [cytosol]
(R-HSA-8867426)
TUBB2B [axonemal microtubule]
(R-HSA-5610432)
TUBB2B [cytosol]
(R-HSA-191705)
0.643
3
UniProt:P52798 EFNA4
3
EFNA4 (26-?) N-ter [extracellular region]
(R-HSA-3928454)
EFNA4 (?-170) C-ter [plasma membrane]
(R-HSA-3928414)
EFNA4 [plasma membrane]
(R-HSA-2682338)
0.59
2
UniProt:P0DP25 CALM
0.569
3
UniProt:P11172 UMPS
1
UMPS [cytosol]
(R-HSA-73487)
0.564
2
UniProt:P07148 FABP1
2
FABP1 [cytosol]
(R-HSA-2026981)
FABP1 [nucleoplasm]
(R-HSA-1989743)
0.564
2
UniProt:P29323 EPHB2
6
EPHB2 (?-?) [plasma membrane]
(R-HSA-3928394)
EPHB2 (?-1055) [cytosol]
(R-HSA-3928432)
EPHB2 (?-1055) [plasma membrane]
(R-HSA-3928386)
EPHB2 (19-?) [extracellular region]
(R-HSA-3928436)
EPHB2 [plasma membrane]
(R-HSA-443809)
p-Y596,Y602-EPHB2 [plasma membrane]
(R-HSA-3928375)
0.539
3
UniProt:Q96PP8 GBP5
1
GBP5 [cytosol]
(R-HSA-1031692)
0.527
2
UniProt:Q9BPY3 F118B
0.527
2
UniProt:O60637 TSN3
0.527
2
UniProt:Q9NRE1 MMP26
0.527
2
UniProt:P05177 CYP1A2
1
CYP1A2 [endoplasmic reticulum membrane]
(R-HSA-52625)
0.527
2
UniProt:Q9UHW5 GPN3
0.527
2
UniProt:P19086 GNAZ
2
p-S27-GNAZ [plasma membrane]
(R-HSA-804942)
GNAZ [plasma membrane]
(R-HSA-167416)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:Q9UHP6 RSP14
0.527
2
UniProt:P04350 TUBB4A
6
TUBB4A [cytosol]
(R-HSA-190588)
TUBB4A [axonemal microtubule]
(R-HSA-5610435)
Polyglutamyl-TUBB4A [cytosol]
(R-HSA-8867425)
Polyglycyl-TUBB4A [cytosol]
(R-HSA-8867397)
TUBB4A unfolded [cytosol]
(R-HSA-392778)
TUBB4A folding intermediate [cytosol]
(R-HSA-392789)
0.527
2
UniProt:Q8WXQ8 CBPA5
0.527
2
UniProt:A4D1S0 KLRG2
0.527
2
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.527
2
UniProt:P35249 RFC4
1
RFC4 [nucleoplasm]
(R-HSA-68429)
0.527
2
UniProt:Q9NSE4 IARS2
1
IARS2 [mitochondrial matrix]
(R-HSA-379571)
0.527
2
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