Reactome | p-T1400,T1412-MAP3K1 [cytosol]

p-T1400,T1412-MAP3K1 [cytosol]

Stable Identifier

R-HSA-2685607

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T1400,T1412-MEKK1

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External Reference Information

External Reference

UniProt:Q13233 MAP3K1

Gene Names

MAP3K1, MAPKKK1, MEKK, MEKK1

Chain

initiator methionine:1, chain:2-1512

Reference Genes

BioGPS Gene:4214 MAP3K1

COSMIC (genes):MAP3K1 MAP3K1

CTD Gene:4214 MAP3K1

dbSNP Gene:4214 MAP3K1

ENSEMBL:ENSG00000095015 MAP3K1

HGNC:6848 MAP3K1

KEGG Gene (Homo sapiens):4214 MAP3K1

Monarch:4214 MAP3K1

NCBI Gene:4214 MAP3K1

OMIM:600982 MAP3K1

UCSC:Q13233 MAP3K1

Reference Transcript

RefSeq:NM_005921.1 MAP3K1

Other Identifiers

0002480440

11728093_a_at

11728094_s_at

16984945

2004_at

214786_at

225927_at

2810339

2810363

2810364

2810366

2810369

2810370

2810371

2810372

2810373

2810374

2810375

2810376

2810377

2810378

2810379

2810380

2810381

2810382

2810383

2810384

2810385

2810386

2810387

2810388

2810389

2810391

2810393

2810394

33009_at

4214

65480_at

8105436

A_33_P3368139

GE54372

GE88576

GO:0000165

GO:0000166

GO:0000186

GO:0002376

GO:0002755

GO:0003674

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0007165

GO:0008150

GO:0008270

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0019901

GO:0038095

GO:0043167

GO:0046872

GO:0071260

Hs.170610.0.A1_3p_at

Hs.298727.0.S1_3p_s_at

ILMN_1723020

PH_hs_0022816

TC05000243.hg

Participant Of

output

Autophosphorylation and activation of MEKK1

Other forms of this molecule

MAP3K1 [cytosol]

Inferred To

phospho-mkh1 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Sus scrofa)

phospho-map3k1 [cytosol] (Danio rerio)

phospho-Map3k1 [cytosol] (Mus musculus)

phospho-Map3k1 [cytosol] (Rattus norvegicus)

phospho-arhgef3.2 [cytosol] (Xenopus tropicalis)

phospho-MAP3K1 [cytosol] (Canis familiaris)

phospho-MAP3K1 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 1400

Coordinate

1400

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 1412

Coordinate

1412

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_005912.1

ZINC - World Drugs

M3K1_HUMAN

OpenTargets

ENSG00000095015

ZINC - FDA approved

M3K1_HUMAN

ZINC - Substances

M3K1_HUMAN

ZINC - Biogenic

M3K1_HUMAN

ZINC target

Q13233

PRO

Q13233

ZINC - Investigational

M3K1_HUMAN

HPA

ENSG00000095015-MAP3K1

GeneCards

Q13233

Ensembl

ENSG00000095015, ENST00000399503, ENSP00000382423

ZINC - Predictions - Purchasable

M3K1_HUMAN

Orphanet

19842

HMDB Protein

HMDBP01134

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.709	7
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.621	3
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF [cytosol] (R-HSA-167224) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.609	2
UniProt:P45985 MAP2K4	4	MAP2K4(1-?) [cytosol] (R-HSA-5211402) MAP2K4(?-399) [cytosol] (R-HSA-5211396) p-S257,T261-MAP2K4 [cytosol] (R-HSA-168170) MAP2K4 [cytosol] (R-HSA-168107)	0.602	3
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.589	2
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.589	2
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.564	2
IntAct:EBI-1108795 NPM			0.499	3
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.499	2

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