Reactome | p-T1400,T1412-MAP3K1 [cytosol]

p-T1400,T1412-MAP3K1 [cytosol]

Stable Identifier

R-HSA-2685607

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T1400,T1412-MEKK1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13233 MAP3K1

Gene Names

MAP3K1, MAPKKK1, MEKK, MEKK1

Chain

initiator methionine:, chain:2-1512

Reference Genes

BioGPS Gene:4214 MAP3K1

COSMIC (genes):MAP3K1 MAP3K1

CTD Gene:4214 MAP3K1

dbSNP Gene:4214 MAP3K1

ENSEMBL:ENSG00000095015 MAP3K1

ENSEMBL_homo_sapiens_GENE:ENSG00000095015.6 MAP3K1

HGNC:6848 MAP3K1

KEGG Gene (Homo sapiens):4214 MAP3K1

Monarch:4214 MAP3K1

NCBI Gene:4214 MAP3K1

OMIM:600982 MAP3K1

UCSC:Q13233 MAP3K1

Reference Transcript

RefSeq:NM_005921.1 MAP3K1

Other Identifiers

11728093_a_at

11728094_s_at

16984945

2004_at

214786_PM_at

214786_at

225927_PM_at

225927_at

2810339

2810363

2810364

2810366

2810369

2810370

2810371

2810372

2810373

2810374

2810375

2810376

2810377

2810378

2810379

2810380

2810381

2810382

2810383

2810384

2810385

2810386

2810387

2810388

2810389

2810391

2810393

2810394

33009_at

4214

65480_at

8105436

A_33_P3368139

GE54372

GE88576

GO:0000165

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006468

GO:0008270

GO:0016301

GO:0016310

GO:0016740

GO:0019901

GO:0023052

GO:0036211

GO:0038095

GO:0046872

GO:0071260

GO:0106310

GO:0140096

HMNXSV003043042

Hs.170610.0.A1_3p_at

Hs.298727.0.S1_3p_s_at

ILMN_1723020

PH_hs_0022816

TC05000243.hg

Participates

as an output of

Autophosphorylation and activation of MEKK1 (Homo sapiens)

Other forms of this molecule

MAP3K1 [cytosol]

Inferred To

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Bos taurus)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Dictyostelium discoideum)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Mus musculus)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Rattus norvegicus)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Sus scrofa)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Xenopus tropicalis)

Homologues of p-T1400,T1412-MAP3K1 [cytosol] (Dictyostelium discoideum)

phospho-MAP3K1 [cytosol] (Canis familiaris)

phospho-MAP3K1 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 1400

Coordinate

1400

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 1412

Coordinate

1412

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_005912.1

ZINC - World Drugs

M3K1_HUMAN

Guide to Pharmacology - Targets

2069

OpenTargets

ENSG00000095015

ZINC - FDA approved

M3K1_HUMAN

ZINC - Substances

M3K1_HUMAN

ZINC target

Q13233

ZINC - Biogenic

M3K1_HUMAN

PRO

Q13233

PDB

6WHB

ZINC - Investigational

M3K1_HUMAN

HPA

ENSG00000095015-MAP3K1

GeneCards

Q13233

Ensembl

ENSG00000095015, ENST00000399503, ENSP00000382423

Pharos - Targets

Q13233

ZINC - Predictions - Purchasable

M3K1_HUMAN

Orphanet

19842

HMDB Protein

HMDBP01134

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.71	4
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.709	7
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.609	2
UniProt:P45985 MAP2K4	4	MAP2K4 [cytosol] (R-HSA-168107) p-S257,T261-MAP2K4 [cytosol] (R-HSA-168170) MAP2K4(1-?) [cytosol] (R-HSA-5211402) MAP2K4(?-399) [cytosol] (R-HSA-5211396)	0.602	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.536	2
UniProt:P34931 HSPA1L	2	HSPA1L [cytosol] (R-HSA-3371410) HSPA1L [nucleoplasm] (R-HSA-5082367)	0.536	2
IntAct:EBI-1108795 NPM			0.499	3
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.499	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.483	2

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