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p-T1400,T1412-MAP3K1 [cytosol]
Stable Identifier
R-HSA-2685607
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-T1400,T1412-MEKK1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Autophosphorylation and activation of MEKK1 (Homo sapiens)
p-T1400,T1412-MAP3K1 [cytosol] (Homo sapiens)
Phosphorylation of MEK4 by MEKK1 (Homo sapiens)
p-T1400,T1412-MAP3K1 [cytosol] (Homo sapiens)
Phosphorylation of MEK7 by MEKK1 (Homo sapiens)
p-T1400,T1412-MAP3K1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13233 MAP3K1
Gene Names
MAP3K1, MAPKKK1, MEKK, MEKK1
Chain
initiator methionine:1, chain:2-1512
Reference Genes
BioGPS Gene:4214 MAP3K1
COSMIC (genes):MAP3K1 MAP3K1
CTD Gene:4214 MAP3K1
dbSNP Gene:4214 MAP3K1
ENSEMBL:ENSG00000095015 MAP3K1
HGNC:6848 MAP3K1
KEGG Gene (Homo sapiens):4214 MAP3K1
Monarch:4214 MAP3K1
NCBI Gene:4214 MAP3K1
OMIM:600982 MAP3K1
UCSC:Q13233 MAP3K1
Reference Transcript
RefSeq:NM_005921.1 MAP3K1
Other Identifiers
0002480440
11728093_a_at
11728094_s_at
16984945
2004_at
214786_at
225927_at
2810339
2810363
2810364
2810366
2810369
2810370
2810371
2810372
2810373
2810374
2810375
2810376
2810377
2810378
2810379
2810380
2810381
2810382
2810383
2810384
2810385
2810386
2810387
2810388
2810389
2810391
2810393
2810394
33009_at
4214
65480_at
8105436
A_33_P3368139
GE54372
GE88576
GO:0000165
GO:0000166
GO:0000186
GO:0002376
GO:0002755
GO:0003674
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0007165
GO:0008150
GO:0008270
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0019901
GO:0038095
GO:0043167
GO:0046872
GO:0071260
Hs.170610.0.A1_3p_at
Hs.298727.0.S1_3p_s_at
ILMN_1723020
PH_hs_0022816
TC05000243.hg
Participant Of
output
Autophosphorylation and activation of MEKK1
Other forms of this molecule
MAP3K1 [cytosol]
Inferred To
phospho-mkh1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T1400,T1412-MAP3K1 [cytosol] (Sus scrofa)
phospho-map3k1 [cytosol] (Danio rerio)
phospho-Map3k1 [cytosol] (Mus musculus)
phospho-Map3k1 [cytosol] (Rattus norvegicus)
phospho-arhgef3.2 [cytosol] (Xenopus tropicalis)
phospho-MAP3K1 [cytosol] (Canis familiaris)
phospho-MAP3K1 [cytosol] (Gallus gallus)
Modified Residues
Name
O-phospho-L-threonine at 1400
Coordinate
1400
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 1412
Coordinate
1412
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_005912.1
ZINC - World Drugs
M3K1_HUMAN
OpenTargets
ENSG00000095015
ZINC - FDA approved
M3K1_HUMAN
ZINC - Substances
M3K1_HUMAN
ZINC - Biogenic
M3K1_HUMAN
ZINC target
Q13233
PRO
Q13233
ZINC - Investigational
M3K1_HUMAN
HPA
ENSG00000095015-MAP3K1
GeneCards
Q13233
Ensembl
ENSG00000095015
,
ENST00000399503
,
ENSP00000382423
ZINC - Predictions - Purchasable
M3K1_HUMAN
Orphanet
19842
HMDB Protein
HMDBP01134
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61962 DCAF7
2
DCAF7 [nucleoplasm]
(R-HSA-8863312)
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
0.709
7
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.621
3
UniProt:P15056 BRAF
68
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF [cytosol]
(R-HSA-167224)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
BRAF G469R [cytosol]
(R-HSA-9648621)
BRAF L597R [cytosol]
(R-HSA-9648617)
BRAF G469E [cytosol]
(R-HSA-9648618)
BRAF L597Q [cytosol]
(R-HSA-9648619)
BRAF G466A [cytosol]
(R-HSA-9648613)
BRAF G466V [cytosol]
(R-HSA-9648838)
BRAF N581S [cytosol]
(R-HSA-9648850)
BRAF G464V [cytosol]
(R-HSA-9648611)
p-BRAF L597V [plasma membrane]
(R-HSA-8936647)
p-BRAF L505H [plasma membrane]
(R-HSA-9648862)
p-BRAF G464E [plasma membrane]
(R-HSA-8936645)
p-BRAF F595L [plasma membrane]
(R-HSA-8936641)
p-BRAF A246P [plasma membrane]
(R-HSA-9651188)
p-BRAF E586K [plasma membrane]
(R-HSA-8936639)
p-BRAF N581D [plasma membrane]
(R-HSA-9651191)
p-BRAF V600K [plasma membrane]
(R-HSA-8936651)
p-BRAF G464V [plasma membrane]
(R-HSA-9648633)
p-BRAF T244P [plasma membrane]
(R-HSA-9651194)
p-BRAF G469E [plasma membrane]
(R-HSA-9648634)
p-BRAF G466V [plasma membrane]
(R-HSA-9648859)
p-BRAF G469V [plasma membrane]
(R-HSA-9648628)
p-BRAF G466A [plasma membrane]
(R-HSA-9648629)
p-BRAF L597Q [plasma membrane]
(R-HSA-9648630)
p-BRAF L597R [plasma membrane]
(R-HSA-9648631)
p-BRAF N581S [plasma membrane]
(R-HSA-9648866)
p-BRAF G469R [plasma membrane]
(R-HSA-9648627)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
BRAF G534R [cytosol]
(R-HSA-9651134)
BRAF S467A [cytosol]
(R-HSA-9651161)
BRAF K601N [cytosol]
(R-HSA-9648857)
BRAF G469A [cytosol]
(R-HSA-6802381)
BRAF L485F [cytosol]
(R-HSA-9651147)
BRAF Q257R [cytosol]
(R-HSA-9651157)
BRAF K499E [cytosol]
(R-HSA-9651142)
BRAF V600E [cytosol]
(R-HSA-6802498)
BRAF K601E [cytosol]
(R-HSA-9648833)
BRAF V600E V169_M438del [cytosol]
(R-HSA-6802489)
BRAF V600E V47_D380del [cytosol]
(R-HSA-6802491)
BRAF V600E V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.609
2
UniProt:P45985 MAP2K4
4
MAP2K4(1-?) [cytosol]
(R-HSA-5211402)
MAP2K4(?-399) [cytosol]
(R-HSA-5211396)
p-S257,T261-MAP2K4 [cytosol]
(R-HSA-168170)
MAP2K4 [cytosol]
(R-HSA-168107)
0.602
3
UniProt:P34931 HSPA1L
2
HSPA1L [nucleoplasm]
(R-HSA-5082367)
HSPA1L [cytosol]
(R-HSA-3371410)
0.589
2
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.589
2
UniProt:P32121 ARRB2
2
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [cytosol]
(R-HSA-416464)
0.564
2
IntAct:EBI-1108795 NPM
0.499
3
UniProt:O75369 FLNB
1
FLNB [cytosol]
(R-HSA-354163)
0.499
2
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