Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-Y452,Y476,Y584-GAB2 [cytosol]
Stable Identifier
R-HSA-2685615
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
PI3K associates with phosphorylated GAB2 (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-Y452,Y476,Y584-GAB2 [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-Y452,Y476,Y584-GAB2 [cytosol] (Homo sapiens)
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-Y452,Y476,Y584-GAB2 [cytosol] (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-Y452,Y476,Y584-GAB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQC2 GAB2
Gene Names
GAB2, KIAA0571
Chain
chain:1-676
Reference Genes
BioGPS Gene:9846 GAB2
COSMIC (genes):GAB2 GAB2
CTD Gene:9846 GAB2
dbSNP Gene:9846 GAB2
ENSEMBL:ENSG00000033327 GAB2
HGNC:14458 GAB2
KEGG Gene (Homo sapiens):9846 GAB2
Monarch:9846 GAB2
NCBI Gene:9846 GAB2
OMIM:606203 GAB2
UCSC:Q9UQC2 GAB2
Reference Transcript
RefSeq:NM_012296.3 GAB2
RefSeq:XM_006718753.2 GAB2
RefSeq:NM_080491.2 GAB2
Other Identifiers
0004760465
0004810487
0006020100
11724867_a_at
11737624_a_at
1368
16742647
203853_s_at
22159
271
2VWF
2W0Z
3383228
3383229
3383230
3383231
3383232
3383233
3383234
3383235
3383236
3383237
3383238
3383239
3383243
3383244
3383258
3383259
3383278
3383295
3383296
35253_at
5EWZ
5EXA
7950671
9846
A_23_P203743
A_24_P98843
AAI31712
AAI52460
AB011143
AB018413
AP002985
BAA25497
BAA76737
BC131711
BC152459
CAB022159
CCDS8259
CCDS8260
CH471076
E9PJ26
E9PJE2
EAW75057
EAW75058
ENSG00000033327
ENSP00000343959
ENSP00000354952
ENST00000340149
ENST00000340149.6
ENST00000361507
ENST00000361507.4
EntrezGene:9846
EntrezGene:GAB2
g6912459_3p_a_at
GAB2
GAB2-201
GAB2-202
GE53283
GO:0000902
GO:0002376
GO:0003674
GO:0005068
GO:0005515
GO:0005547
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005886
GO:0006810
GO:0007165
GO:0007169
GO:0007411
GO:0008150
GO:0008283
GO:0008284
GO:0008289
GO:0016020
GO:0016192
GO:0019221
GO:0019899
GO:0030154
GO:0030316
GO:0030674
GO:0038095
GO:0040011
GO:0043167
GO:0043306
GO:0043325
GO:0048015
GO:0048856
HGNC:14458
HPA000271
HPA001368
ILMN_1665964
ILMN_1728746
ILMN_1791143
ILMN_1815758
IPR001849
IPR011993
MIM:606203
NM_012296
NM_080491
NP_036428
NP_536739
PF00169
PH_hs_0002620
SM00233
TC11002136.hg
UPI0000073037
UPI00001615CF
XM_006718753
XM_011545408
XM_024448782
XP_006718816
XP_011543710
XP_024304550
Participant Of
hasComponent
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane]
Other forms of this molecule
GAB2 [cytosol]
p-Y-GAB2 [cytosol]
p-5Y-GAB2 [cytosol]
Inferred To
Ghost homologue of p-Y452,Y476,Y584-GAB2 [cytosol] (Gallus gallus)
phospho-p-Y452,Y476,Y584-GAB2 [cytosol] (Bos taurus)
phospho-p-Y452,Y476,Y584-GAB2 [cytosol] (Canis familiaris)
phospho-p-Y452,Y476,Y584-GAB2 [cytosol] (Danio rerio)
phospho-p-Y452,Y476,Y584-GAB2 [cytosol] (Drosophila melanogaster)
phospho-p-Y452,Y476,Y584-GAB2 [cytosol] (Mus musculus)
phospho-p-Y452,Y476,Y584-GAB2 [cytosol] (Rattus norvegicus)
phospho-p-Y452,Y476,Y584-GAB2 [cytosol] (Sus scrofa)
phospho-p-Y452,Y476,Y584-GAB2 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 452
Coordinate
452
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 476
Coordinate
476
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 584
Coordinate
584
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_536739.1
,
NP_036428.1
,
XP_006718816.1
OpenTargets
ENSG00000033327
GeneCards
Q9UQC2
PRO
Q9UQC2
Orphanet
28320
PDB
5EXA
,
5EWZ
,
2VWF
,
2W0Z
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.941
12
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
0.643
4
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
0.564
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.558
4
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.544
2
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.527
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.527
2
UniProt:A0A024R8L2 A0A024R8L2
0.488
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.488
2
© 2019
Reactome