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About
What is Reactome ?
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Team
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Release Calendar
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Privacy Notice
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Digital Preservation
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Table of Contents
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p-SHC1:GRB2:SOS [cytosol]
Stable Identifier
R-HSA-2685672
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Activation of RAC1 by VAV2/3 (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Release of p-PLCG1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Autophosphorylation of BTK/ITK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of VAV to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
PI3K associates with phosphorylated GAB2 (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Participants
components
GRB2-1:SOS1 [cytosol]
(Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol]
(Homo sapiens)
Participates
as an input of
Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
as a component of
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
as an output of
Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)
Inferred To
p-SHC1:GRB2:SOS [cytosol]
(Bos taurus)
p-SHC1:GRB2:SOS [cytosol]
(Canis familiaris)
p-SHC1:GRB2:SOS [cytosol]
(Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol]
(Gallus gallus)
p-SHC1:GRB2:SOS [cytosol]
(Mus musculus)
p-SHC1:GRB2:SOS [cytosol]
(Rattus norvegicus)
p-SHC1:GRB2:SOS [cytosol]
(Sus scrofa)
p-SHC1:GRB2:SOS [cytosol]
(Xenopus tropicalis)
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