Reactome | K63polyUb-TRAF6 [cytosol]

K63polyUb-TRAF6 [cytosol]

Stable Identifier

R-HSA-2685681

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63-polyubiquitinated TRAF6, Oligo-K63-poly Ub-TRAF6, Poly-ubiquitinated TRAF6

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Signal Transduction (Homo sapiens)

- Death Receptor Signalling (Homo sapiens)
  - p75 NTR receptor-mediated signalling (Homo sapiens)
    - p75NTR signals via NF-kB (Homo sapiens)
      - p75NTR recruits signalling complexes (Homo sapiens)
        
        TRAF6 is auto-ubiquitinated (Homo sapiens)
        
        NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Homo sapiens)
        
        K63polyUb-TRAF6 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
17135271	Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation Lamothe, B, Besse, A, Campos, AD, Webster, WK, Wu, H, Darnay, BG	J Biol Chem	2007

External Reference Information

External Reference

UniProt:Q9Y4K3 TRAF6

Gene Names

TRAF6, RNF85

Chain

chain:1-522

Reference Genes

BioGPS Gene:7189 TRAF6

COSMIC (genes):TRAF6 TRAF6

CTD Gene:7189 TRAF6

dbSNP Gene:7189 TRAF6

ENSEMBL:ENSG00000175104 TRAF6

HGNC:12036 TRAF6

KEGG Gene (Homo sapiens):7189 TRAF6

Monarch:7189 TRAF6

NCBI Gene:7189 TRAF6

OMIM:602355 TRAF6

UCSC:Q9Y4K3 TRAF6

Reference Transcript

Other Identifiers

0002630132

0003800670

11744243_a_at

1209_at

16737401

205558_at

227264_at

3290612

3290616

3369887

3369889

3369891

3369892

3369893

3369894

3369895

3369896

3369898

3369899

3369902

3369903

3369904

3369905

3369906

3369907

3369913

3369914

53334_at

61369_at

7189

74236_at

7947540

82386_at

A_23_P75921

A_32_P192984

GE59433

GO:0000122

GO:0000187

GO:0000209

GO:0001503

GO:0001843

GO:0002223

GO:0002224

GO:0002376

GO:0002726

GO:0002755

GO:0003674

GO:0004842

GO:0005164

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005768

GO:0005811

GO:0005829

GO:0005886

GO:0005938

GO:0006464

GO:0006810

GO:0006950

GO:0006955

GO:0006974

GO:0007155

GO:0007165

GO:0007249

GO:0007250

GO:0007254

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0009058

GO:0009790

GO:0009887

GO:0009898

GO:0010008

GO:0015031

GO:0016567

GO:0016579

GO:0016740

GO:0019221

GO:0019886

GO:0019899

GO:0019901

GO:0030154

GO:0030316

GO:0031293

GO:0031398

GO:0031410

GO:0031435

GO:0031624

GO:0031625

GO:0031666

GO:0031996

GO:0032147

GO:0032735

GO:0032743

GO:0032755

GO:0032991

GO:0033209

GO:0034162

GO:0034641

GO:0035631

GO:0038095

GO:0042088

GO:0042102

GO:0042475

GO:0042592

GO:0042802

GO:0042826

GO:0042981

GO:0043011

GO:0043065

GO:0043066

GO:0043122

GO:0043123

GO:0043167

GO:0043226

GO:0043422

GO:0043507

GO:0045453

GO:0045672

GO:0045892

GO:0045944

GO:0046330

GO:0046849

GO:0046872

GO:0047485

GO:0048468

GO:0048471

GO:0048646

GO:0048661

GO:0048856

GO:0050852

GO:0051023

GO:0051091

GO:0051092

GO:0051865

GO:0061630

GO:0070423

GO:0070498

GO:0070534

GO:0070555

GO:0071222

GO:0071345

GO:1901224

GO:1904996

GO:2000679

Hs.296272.0.A1_3p_at

ILMN_1700353

ILMN_1783910

ILMN_2392143

PH_hs_0005066

PH_hs_0037121

TC11001560.hg

TC11003120.hg

U78798_at

g4759253_3p_at

Participant Of

hasComponent

hasMember

K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol]

repeatedUnit

K63polyUb-TRAF6 oligomer [cytosol]

Other forms of this molecule

K48polyUb-TRAF6 [cytosol]

TRAF6 [cytosol]

K63polyUb-TRAF6 [plasma membrane]

K63polyUb-TRAF6 [endosome membrane]

TRAF6 [plasma membrane]

TRAF6 [endosome membrane]

PolyUb-TRAF6 [cytosol]

Inferred To

Ghost homologue of K63polyUb-TRAF6 [cytosol] (Caenorhabditis elegans)

Ghost homologue of K63polyUb-TRAF6 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of K63polyUb-TRAF6 [cytosol] (Schizosaccharomyces pombe)

K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)

Traf6 [cytosol] (Drosophila melanogaster)

Traf6 [cytosol] (Mus musculus)

Traf6 [cytosol] (Rattus norvegicus)

TRAF6 [cytosol] (Bos taurus)

TRAF6 [cytosol] (Canis familiaris)

TRAF6 [cytosol] (Gallus gallus)

TRAF6 [cytosol] (Sus scrofa)

traf6 [cytosol] (Danio rerio)

traf6 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 124

Coordinate

124

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_004611.1, NP_665802.1

OpenTargets

ENSG00000175104

GeneCards

Q9Y4K3

HPA

ENSG00000175104-TRAF6

Ensembl

ENSP00000337853, ENSG00000175104, ENSP00000433623, ENST00000348124, ENST00000526995

PRO

Q9Y4K3

Orphanet

21836

PDB

3HCS, 6A33, 4Z8M, 1LB4, 1LB6, 2ECI, 1LB5, 2JMD, 3HCT, 3HCU, 5ZUJ

Interactors (69)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [plasma membrane] (R-HSA-936955) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845)	0.919	11
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.911	17
UniProt:O00463 TRAF5			0.879	15
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.871	9
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [cytosol] (R-HSA-8864210) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.847	9
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.797	8
IntAct:EBI-4399559 UBIQ			0.77	5
UniProt:O43187 IRAK2	6	p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [endosome membrane] (R-HSA-975116) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.752	4
UniProt:P07947 YES1	2	YES1 [cytosol] (R-HSA-373640) MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411)	0.718	6
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.718	6
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.71	4
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628)	0.708	5
UniProt:Q96CG3 TIFA	2	p-T9-TIFA [cytosol] (R-HSA-9645512) TIFA [cytosol] (R-HSA-451582)	0.702	6
UniProt:P51617 IRAK1	14	p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011)	0.702	3
UniProt:P0CG48 UBC	325	UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-566-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-338-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-186-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-262-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-414-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-110-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-642-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-488-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130) Ub-443-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783153) Ub-139-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783155) Ub-63-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783094) Ub-671-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783083) Ub-519-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783053) Ub-367-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783105) Ub-215-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783137) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122) Ub-310-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783027) Ub-234-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783157) Ub-614-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783063) Ub-462-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783118) Ub-538-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783011) Ub-158-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783140) Ub-82-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783175) Ub-315-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783089) Ub-163-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783091) Ub-543-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783060) Ub-239-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783092) Ub-619-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783125) Ub-467-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783181) Ub-11-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783104) Ub-391-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783170) Ub-87-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783110) Ub-656-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783134) Ub-124-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783120) Ub-428-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783090) Ub-48-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783029) Ub-504-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783113) Ub-200-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783150) Ub-580-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783119) Ub-276-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783183) Ub-352-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783201) Ub-29-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783064) Ub-182-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783097) Ub-486-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783194) Ub-334-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783199) Ub-638-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783188) Ub-106-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783031) Ub-258-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783016) Ub-562-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783172) Ub-410-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783077) Ub-636-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783128) Ub-104-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783032) Ub-256-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783004) Ub-484-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783156) Ub-27-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783022) Ub-332-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783138) Ub-180-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783107) Ub-408-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783108) Ub-560-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783174) N6-glycyl-L-lysine-UBC(457-532) [cytosol] (R-HSA-8869048) N6-glycyl-L-lysine-UBC(609-684) [cytosol] (R-HSA-8869052) N6-glycyl-L-lysine-UBC(229-304) [cytosol] (R-HSA-8869032) N6-glycyl-L-lysine-UBC(533-608) [cytosol] (R-HSA-8869033) N6-glycyl-L-lysine-UBC(153-228) [cytosol] (R-HSA-8869035) N6-glycyl-L-lysine-UBC(305-380) [cytosol] (R-HSA-8869036) N6-glycyl-L-lysine-UBC(77-152) [cytosol] (R-HSA-8869026) N6-glycyl-L-lysine-UBC(1-76) [cytosol] (R-HSA-8869030) N6-glycyl-L-lysine-UBC(381-456) [cytosol] (R-HSA-8869031) adenylatedG608-UBC(533-608) [nucleoplasm] (R-HSA-8852090) adenylatedG380-UBC(305-380) [nucleoplasm] (R-HSA-8852093) adenylatedG532-UBC(457-532) [nucleoplasm] (R-HSA-8852081) adenylatedG304-UBC(229-304) [nucleoplasm] (R-HSA-8852050) adenylatedG152-UBC(77-152) [nucleoplasm] (R-HSA-8852054) adenylatedG684-UBC(609-684) [nucleoplasm] (R-HSA-8852105) adenylatedG228-UBC(153-228) [nucleoplasm] (R-HSA-8852075) adenylatedG76-UBC(1-76) [nucleoplasm] (R-HSA-8852044) adenylatedG456-UBC(381-456) [nucleoplasm] (R-HSA-8852098) UBC [cytosol] (R-HSA-8853531) adenylatedG380-UBC(305-380) [cytosol] (R-HSA-8852062) adenylatedG608-UBC(533-608) [cytosol] (R-HSA-8852052) adenylatedG76-UBC(1-76) [cytosol] (R-HSA-8852053) adenylatedG304-UBC(229-304) [cytosol] (R-HSA-8852117) adenylatedG684-UBC(609-684) [cytosol] (R-HSA-8852118) adenylatedG152-UBC(77-152) [cytosol] (R-HSA-8852087) adenylatedG532-UBC(457-532) [cytosol] (R-HSA-8852045) adenylatedG228-UBC(153-228) [cytosol] (R-HSA-8852111) adenylatedG456-UBC(381-456) [cytosol] (R-HSA-8852069) Ub-428-UBC(381-456) [endoplasmic reticulum membrane] (R-HSA-8943062) Ub-656-UBC(609-684) [endoplasmic reticulum membrane] (R-HSA-8943120) Ub-124-UBC(77-152) [endoplasmic reticulum membrane] (R-HSA-8943129) Ub-48-UBC(1-76) [endoplasmic reticulum membrane] (R-HSA-8943079) Ub-352-UBC(305-380) [endoplasmic reticulum membrane] (R-HSA-8943108) Ub-504-UBC(457-532) [endoplasmic reticulum membrane] (R-HSA-8943075) Ub-276-UBC(229-304) [endoplasmic reticulum membrane] (R-HSA-8943106) Ub-580-UBC(533-608) [endoplasmic reticulum membrane] (R-HSA-8943137) Ub-200-UBC(153-228) [endoplasmic reticulum membrane] (R-HSA-8943087) UBC(1-76) [plasma membrane] (R-HSA-3149469) UBC(457-532) [plasma membrane] (R-HSA-3149468) UBC(153-228) [plasma membrane] (R-HSA-3149467) UBC(609-684) [plasma membrane] (R-HSA-3149466) UBC(77-152) [plasma membrane] (R-HSA-3149465) UBC(229-304) [plasma membrane] (R-HSA-3149464) UBC(533-608) [plasma membrane] (R-HSA-3149462) UBC(381-456) [plasma membrane] (R-HSA-3149459) UBC(305-380) [plasma membrane] (R-HSA-3149458) UBC(1-76) [endosome membrane] (R-HSA-939187) UBC(533-608) [endosome membrane] (R-HSA-939221) UBC(77-152) [endosome membrane] (R-HSA-939161) UBC(305-380) [endosome membrane] (R-HSA-939196) UBC(457-532) [endosome membrane] (R-HSA-939199) UBC(381-456) [endosome membrane] (R-HSA-939166) UBC(153-228) [endosome membrane] (R-HSA-939170) UBC(609-684) [endosome membrane] (R-HSA-939237) UBC(229-304) [endosome membrane] (R-HSA-939172) UBC(77-152) [endoplasmic reticulum membrane] (R-HSA-8943095) UBC(381-456) [endoplasmic reticulum membrane] (R-HSA-8943126) UBC(533-608) [endoplasmic reticulum membrane] (R-HSA-8943061) UBC(609-684) [endoplasmic reticulum membrane] (R-HSA-8943135) UBC(229-304) [endoplasmic reticulum membrane] (R-HSA-8943103) UBC(153-228) [endoplasmic reticulum membrane] (R-HSA-8943068) UBC(1-76) [endoplasmic reticulum membrane] (R-HSA-8943077) UBC(305-380) [endoplasmic reticulum membrane] (R-HSA-8943084) UBC(457-532) [endoplasmic reticulum membrane] (R-HSA-8943112) Ub-29-UBC(1-76) [cytosol] (R-HSA-5689165) Ub-258-UBC(229-304) [cytosol] (R-HSA-5689167) Ub-334-UBC(305-380) [cytosol] (R-HSA-5689166) Ub-410-UBC(381-456) [cytosol] (R-HSA-5689185) Ub-486-UBC(457-532) [cytosol] (R-HSA-5689176) Ub-562-UBC(533-608) [cytosol] (R-HSA-5689151) Ub-106-UBC(77-152) [cytosol] (R-HSA-5689183) Ub-182-UBC(153-228) [cytosol] (R-HSA-5689169) Ub-638-UBC(609-684) [cytosol] (R-HSA-5689136) Ub-87-UBC(77-152) [cytosol] (R-HSA-3095920) Ub-163-UBC(153-228) [cytosol] (R-HSA-3095924) Ub-619-UBC(609-684) [cytosol] (R-HSA-3095925) Ub-467-UBC(457-532) [cytosol] (R-HSA-3095935) Ub-11-UBC(1-76) [cytosol] (R-HSA-3095906) Ub-543-UBC(533-608) [cytosol] (R-HSA-3095912) Ub-391-UBC(381-456) [cytosol] (R-HSA-3095914) Ub-315-UBC(305-380) [cytosol] (R-HSA-3095916) Ub-239-UBC(229-304) [cytosol] (R-HSA-3095919) Ub-310-UBC(305-380) [cytosol] (R-HSA-5689097) Ub-6-UBC(1-76) [cytosol] (R-HSA-5689091) Ub-462-UBC(457-532) [cytosol] (R-HSA-5689092) Ub-386-UBC(381-456) [cytosol] (R-HSA-5689086) Ub-538-UBC(533-608) [cytosol] (R-HSA-5689104) Ub-158-UBC(153-228) [cytosol] (R-HSA-5689107) Ub-614-UBC(609-684) [cytosol] (R-HSA-5689076) Ub-234-UBC(229-304) [cytosol] (R-HSA-5689110) Ub-82-UBC(77-152) [cytosol] (R-HSA-5689078) Ub-110-UBC(77-152) [cytosol] (R-HSA-5689196) Ub-33-UBC(1-76) [cytosol] (R-HSA-5689134) Ub-488-UBC(457-532) [cytosol] (R-HSA-5689153) Ub-338-UBC(305-380) [cytosol] (R-HSA-5689152) Ub-642-UBC(609-684) [cytosol] (R-HSA-5689218) Ub-414-UBC(381-456) [cytosol] (R-HSA-5689157) Ub-262-UBC(229-304) [cytosol] (R-HSA-5689150) Ub-566-UBC(533-608) [cytosol] (R-HSA-5689205) Ub-186-UBC(153-228) [cytosol] (R-HSA-5689140) Ub-256-UBC(229-304) [cytosol] (R-HSA-5689135) Ub-180-UBC(153-228) [cytosol] (R-HSA-5689221) Ub-104-UBC(77-152) [cytosol] (R-HSA-5689189) Ub-484-UBC(457-532) [cytosol] (R-HSA-5689220) Ub-560-UBC(533-608) [cytosol] (R-HSA-5689145) Ub-636-UBC(609-684) [cytosol] (R-HSA-5689144) Ub-332-UBC(305-380) [cytosol] (R-HSA-5689211) Ub-27-UBC(1-76) [cytosol] (R-HSA-5689179) Ub-408-UBC(381-456) [cytosol] (R-HSA-5689182) Ub-519-UBC(457-532) [endosome membrane] (R-HSA-939227) Ub-367-UBC(305-380) [endosome membrane] (R-HSA-939162) Ub-291-UBC(229-304) [endosome membrane] (R-HSA-939226) Ub-443-UBC(381-456) [endosome membrane] (R-HSA-939204) Ub-215-UBC(153-228) [endosome membrane] (R-HSA-939175) Ub-63-UBC(1-76) [endosome membrane] (R-HSA-939174) Ub-595-UBC(533-608) [endosome membrane] (R-HSA-939242) Ub-139-UBC(77-152) [endosome membrane] (R-HSA-939244) Ub-671-UBC(609-684) [endosome membrane] (R-HSA-939183) Ub-291-UBC(229-304) [plasma membrane] (R-HSA-939859) Ub-595-UBC(533-608) [plasma membrane] (R-HSA-939858) Ub-367-UBC(305-380) [plasma membrane] (R-HSA-939861) Ub-63-UBC(1-76) [plasma membrane] (R-HSA-939860) Ub-139-UBC(77-152) [plasma membrane] (R-HSA-939865) Ub-215-UBC(153-228) [plasma membrane] (R-HSA-939864) Ub-519-UBC(457-532) [plasma membrane] (R-HSA-939845) Ub-671-UBC(609-684) [plasma membrane] (R-HSA-939846) Ub-443-UBC(381-456) [plasma membrane] (R-HSA-939848) Ub-408-UBC(381-456) [nucleoplasm] (R-HSA-6782681) Ub-484-UBC(457-532) [nucleoplasm] (R-HSA-6782650) Ub-104-UBC(77-152) [nucleoplasm] (R-HSA-6782651) Ub-256-UBC(229-304) [nucleoplasm] (R-HSA-6782641) Ub-180-UBC(153-228) [nucleoplasm] (R-HSA-6782603) Ub-560-UBC(533-608) [nucleoplasm] (R-HSA-6782637) Ub-27-UBC(1-76) [nucleoplasm] (R-HSA-6782625) Ub-636-UBC(609-684) [nucleoplasm] (R-HSA-6782597) Ub-332-UBC(305-380) [nucleoplasm] (R-HSA-6782630) Ub-638-UBC(609-684) [nucleoplasm] (R-HSA-6782680) Ub-258-UBC(229-304) [nucleoplasm] (R-HSA-6782621) Ub-562-UBC(533-608) [nucleoplasm] (R-HSA-6782672) Ub-410-UBC(381-456) [nucleoplasm] (R-HSA-6782642) Ub-182-UBC(153-228) [nucleoplasm] (R-HSA-6782678) Ub-106-UBC(77-152) [nucleoplasm] (R-HSA-6782602) Ub-334-UBC(305-380) [nucleoplasm] (R-HSA-6782638) Ub-29-UBC(1-76) [nucleoplasm] (R-HSA-6782659) Ub-486-UBC(457-532) [nucleoplasm] (R-HSA-6782661) Ub-48-UBC(1-76) [nucleoplasm] (R-HSA-6782524) Ub-428-UBC(381-456) [nucleoplasm] (R-HSA-6782462) Ub-504-UBC(457-532) [nucleoplasm] (R-HSA-6782512) Ub-276-UBC(229-304) [nucleoplasm] (R-HSA-6782482) Ub-200-UBC(153-228) [nucleoplasm] (R-HSA-6782487) Ub-656-UBC(609-684) [nucleoplasm] (R-HSA-6782474) Ub-580-UBC(533-608) [nucleoplasm] (R-HSA-6782477) Ub-124-UBC(77-152) [nucleoplasm] (R-HSA-6782498) Ub-352-UBC(305-380) [nucleoplasm] (R-HSA-6782467) Ub-467-UBC(457-532) [nucleoplasm] (R-HSA-6782619) Ub-163-UBC(153-228) [nucleoplasm] (R-HSA-6782622) Ub-11-UBC(1-76) [nucleoplasm] (R-HSA-6782609) Ub-87-UBC(77-152) [nucleoplasm] (R-HSA-6782632) Ub-239-UBC(229-304) [nucleoplasm] (R-HSA-6782669) Ub-543-UBC(533-608) [nucleoplasm] (R-HSA-6782594) Ub-391-UBC(381-456) [nucleoplasm] (R-HSA-6782626) Ub-315-UBC(305-380) [nucleoplasm] (R-HSA-6782660) Ub-619-UBC(609-684) [nucleoplasm] (R-HSA-6782662) Ub-186-UBC(153-228) [nucleoplasm] (R-HSA-6782617) Ub-338-UBC(305-380) [nucleoplasm] (R-HSA-6782620) Ub-33-UBC(1-76) [nucleoplasm] (R-HSA-6782653) Ub-110-UBC(77-152) [nucleoplasm] (R-HSA-6782590) Ub-262-UBC(229-304) [nucleoplasm] (R-HSA-6782640) Ub-642-UBC(609-684) [nucleoplasm] (R-HSA-6782674) Ub-566-UBC(533-608) [nucleoplasm] (R-HSA-6782646) Ub-414-UBC(381-456) [nucleoplasm] (R-HSA-6782636) Ub-488-UBC(457-532) [nucleoplasm] (R-HSA-6782599) Ub-82-UBC(77-152) [nucleoplasm] (R-HSA-6782675) Ub-6-UBC(1-76) [nucleoplasm] (R-HSA-6782611) Ub-234-UBC(229-304) [nucleoplasm] (R-HSA-6782677) Ub-158-UBC(153-228) [nucleoplasm] (R-HSA-6782645) Ub-310-UBC(305-380) [nucleoplasm] (R-HSA-6782614) Ub-538-UBC(533-608) [nucleoplasm] (R-HSA-6782664) Ub-462-UBC(457-532) [nucleoplasm] (R-HSA-6782634) Ub-386-UBC(381-456) [nucleoplasm] (R-HSA-6782605) Ub-614-UBC(609-684) [nucleoplasm] (R-HSA-6782657) UBC(229-304) [nucleoplasm] (R-HSA-939857) UBC(381-456) [nucleoplasm] (R-HSA-939856) UBC(305-380) [nucleoplasm] (R-HSA-939863) UBC(457-532) [nucleoplasm] (R-HSA-939862) UBC(533-608) [nucleoplasm] (R-HSA-939866) UBC(77-152) [nucleoplasm] (R-HSA-939869) UBC(609-684) [nucleoplasm] (R-HSA-939868) UBC(1-76) [nucleoplasm] (R-HSA-939871) UBC(153-228) [nucleoplasm] (R-HSA-939853) Ub-124-UBC(77-152) [nucleoplasm] (R-HSA-5683048) Ub-580-UBC(533-608) [nucleoplasm] (R-HSA-5683050) Ub-428-UBC(381-456) [nucleoplasm] (R-HSA-5683041) Ub-276-UBC(229-304) [nucleoplasm] (R-HSA-5683042) Ub-352-UBC(305-380) [nucleoplasm] (R-HSA-5683045) Ub-200-UBC(153-228) [nucleoplasm] (R-HSA-5683046) Ub-48-UBC(1-76) [nucleoplasm] (R-HSA-5683033) Ub-656-UBC(609-684) [nucleoplasm] (R-HSA-5683035) Ub-504-UBC(457-532) [nucleoplasm] (R-HSA-5683039) Ub-671-UBC(609-684) [nucleoplasm] (R-HSA-6782523) Ub-215-UBC(153-228) [nucleoplasm] (R-HSA-6782491) Ub-63-UBC(1-76) [nucleoplasm] (R-HSA-6782492) Ub-443-UBC(381-456) [nucleoplasm] (R-HSA-6782480) Ub-367-UBC(305-380) [nucleoplasm] (R-HSA-6782479) Ub-139-UBC(77-152) [nucleoplasm] (R-HSA-6782496) Ub-519-UBC(457-532) [nucleoplasm] (R-HSA-6782497) Ub-595-UBC(533-608) [nucleoplasm] (R-HSA-6782499) Ub-291-UBC(229-304) [nucleoplasm] (R-HSA-6782500) UBC(609-684) [late endosome lumen] (R-HSA-9660012) UBC(153-228) [late endosome lumen] (R-HSA-9659979) UBC(305-380) [late endosome lumen] (R-HSA-9660033) UBC(77-152) [late endosome lumen] (R-HSA-9659992) UBC(533-608) [late endosome lumen] (R-HSA-9659993) UBC(229-304) [late endosome lumen] (R-HSA-9659994) UBC(457-532) [late endosome lumen] (R-HSA-9659995) UBC(381-456) [late endosome lumen] (R-HSA-9660023) UBC(1-76) [late endosome lumen] (R-HSA-9659985) Ub-48-UBC(1-76) [cytosol] (R-HSA-939219) Ub-656-UBC(609-684) [cytosol] (R-HSA-939255) Ub-428-UBC(381-456) [cytosol] (R-HSA-939190) Ub-504-UBC(457-532) [cytosol] (R-HSA-939257) Ub-580-UBC(533-608) [cytosol] (R-HSA-939256) Ub-276-UBC(229-304) [cytosol] (R-HSA-939207) Ub-124-UBC(77-152) [cytosol] (R-HSA-939209) Ub-200-UBC(153-228) [cytosol] (R-HSA-939179) Ub-352-UBC(305-380) [cytosol] (R-HSA-939181) UBC(457-532) [cytosol] (R-HSA-939184) UBC(1-76) [cytosol] (R-HSA-939188) UBC(381-456) [cytosol] (R-HSA-939191) UBC(229-304) [cytosol] (R-HSA-939192) UBC(153-228) [cytosol] (R-HSA-939258) UBC(609-684) [cytosol] (R-HSA-939165) UBC(77-152) [cytosol] (R-HSA-939164) UBC(305-380) [cytosol] (R-HSA-939232) UBC(533-608) [cytosol] (R-HSA-939239) UBC(1-76) [lysosomal lumen] (R-HSA-9659981) UBC(305-380) [lysosomal lumen] (R-HSA-9660008) UBC(77-152) [lysosomal lumen] (R-HSA-9659978) UBC(609-684) [lysosomal lumen] (R-HSA-9660020) UBC(153-228) [lysosomal lumen] (R-HSA-9659988) UBC(457-532) [lysosomal lumen] (R-HSA-9659989) UBC(381-456) [lysosomal lumen] (R-HSA-9659984) UBC(229-304) [lysosomal lumen] (R-HSA-9660018) UBC(533-608) [lysosomal lumen] (R-HSA-9659987) Ub-215-UBC(153-228) [cytosol] (R-HSA-939186) Ub-139-UBC(77-152) [cytosol] (R-HSA-939254) Ub-595-UBC(533-608) [cytosol] (R-HSA-939198) Ub-291-UBC(229-304) [cytosol] (R-HSA-939173) Ub-367-UBC(305-380) [cytosol] (R-HSA-939206) Ub-671-UBC(609-684) [cytosol] (R-HSA-939241) Ub-63-UBC(1-76) [cytosol] (R-HSA-939176) Ub-519-UBC(457-532) [cytosol] (R-HSA-939212) Ub-443-UBC(381-456) [cytosol] (R-HSA-939182)	0.702	3
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.688	5
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.688	3
UniProt:Q13501 SQSTM1	2	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961)	0.688	4
UniProt:Q9NYJ8 TAB2	5	TAB2 [endosome membrane] (R-HSA-450279) TAB2 [cytosol] (R-HSA-168117) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323) TAB2 [cytosol] (R-HSA-500563)	0.678	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.675	4
UniProt:Q9Y616 IRAK3	1	IRAK3 [cytosol] (R-HSA-166103)	0.675	4
UniProt:O43318 MAP3K7	10	p-T187-MAP3K7 [cytosol] (R-HSA-206014) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.669	3
UniProt:O43734 CIKS			0.666	4
UniProt:P61077 UBE2D3	3	UBE2D3 [cytosol] (R-HSA-934630) Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [nucleoplasm] (R-HSA-205341)	0.658	3
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.591	3
UniProt:P25942 CD40			0.59	2
UniProt:P07174 Ngfr	8	Ngfr [extracellular region] (R-RNO-194470) Ngfr [nucleoplasm] (R-RNO-197473) Ngfr [endosome] (R-RNO-209541) Ngfr [plasma membrane] (R-RNO-194509) Ngfr [cytosol] (R-RNO-194458) Ngfr [plasma membrane] (R-RNO-194476) Tumor necrosis factor receptor superfamily member 16 [plasma membrane] (R-RNO-193863) Ngfr [plasma membrane] (R-RNO-193664)	0.589	2
UniProt:P28074 PSMB5	2	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344)	0.589	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.589	2
UniProt:P99999 CYCS	4	CYCS [mitochondrial intermembrane space] (R-HSA-114244) CYCS [mitochondrial inner membrane] (R-HSA-352608) CYCS [cytosol] (R-HSA-53259) AcK-CYCS [mitochondrial intermembrane space] (R-HSA-5688308)	0.589	2
UniProt:Q9UNM6 PSMD13	5	PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.589	2
UniProt:Q15008 PSMD6	5	PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.589	2
UniProt:O00232 PSMD12	5	PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.589	2
UniProt:P51665 PSMD7	5	PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.589	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.589	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.589	2
UniProt:Q13200 PSMD2	5	PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.589	2
UniProt:Q14257 RCN2			0.589	2
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.589	2
UniProt:Q99558 MAP3K14	5	MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.589	2
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.573	2
UniProt:Q9HAV5 EDA2R	1	EDA2R [plasma membrane] (R-HSA-5669018)	0.564	2
UniProt:Q8IWQ3-3 BRSK2			0.556	3
UniProt:Q9UNA4 POLI	1	POLI [nucleoplasm] (R-HSA-5656133)	0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:P15732 UBC5			0.556	3
UniProt:Q9HAC8 UBTD1			0.556	3
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	5
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q8V2D1 Q8V2D1			0.556	3
UniProt:Q96DC9 OTUB2	2	OTUB2 [cytosol] (R-HSA-933410) OTUB2 [nucleoplasm] (R-HSA-6783260)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P24278 ZBT25			0.556	3
UniProt:O75604 USP2	2	USP2 [nucleoplasm] (R-HSA-5689946) USP2 [cytosol] (R-HSA-5212661)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.556	3
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	5
UniProt:Q8TD23 ZNF675	1	ZNF675 [nucleoplasm] (R-HSA-2248874)	0.543	4
UniProt:Q15750 TAB1	2	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238)	0.527	2
UniProt:P51668 UBE2D1	3	UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) UBE2D1 [cytosol] (R-HSA-174236)	0.527	2
UniProt:P10221 ITP			0.524	3
UniProt:Q01220 A52			0.524	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.524	2
UniProt:P14778 IL1R1	1	IL1R1 [plasma membrane] (R-HSA-197595)	0.499	2
UniProt:Q9C0C7-3 AMBRA1			0.499	2
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [recycling endosome] (R-HSA-8854761) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131)	0.499	2
UniProt:O14836 TNFRSF13B	1	TAC1 [plasma membrane] (R-HSA-5668752)	0.462	2