NOTCH1 HD domain mutants bind DLL1

Stable Identifier
R-HSA-2691219
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NOTCH1 HD domain mutants bind DLL1
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DLL1 binds to NOTCH1 HD (heterodimerization) domain mutants, thereby activating them and stimulating signaling (Malecki et al. 2006).
Literature References
PubMed ID Title Journal Year
16738328 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Mitchell, JL, Malecki, MJ, Blacklow, SC, Xu, ML, Sanchez-Irizarry, C, Aster, JC, Histen, G

Mol. Cell. Biol. 2006
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Normal reaction
NOTCH1 binds DLL1 (Homo sapiens)
Functional status

Gain of function of NOTCH1 HD domain mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-12-04)
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