Signaling by NOTCH1 HD Domain Mutants in Cancer

Stable Identifier
R-HSA-2691230
Type
Pathway
Species
Homo sapiens
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NOTCH1 heterodimerization domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL) (Weng et al. 2004) and result in constitutive activity of NOTCH1 mutants (Malecki et al. 2006).

Literature References
PubMed ID Title Journal Year
16738328 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Malecki, MJ, Sanchez-Irizarry, C, Mitchell, JL, Histen, G, Xu, ML, Aster, JC, Blacklow, SC

Mol. Cell. Biol. 2006
15472075 Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Weng, AP, Ferrando, AA, Lee, W, Morris JP, 4th, Silverman, LB, Sanchez-Irizarry, C, Blacklow, SC, Look, AT, Aster, JC

Science 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created