CLCN4/5/6 exchange Cl- for H+

Stable Identifier
R-HSA-2730692
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The H+/Cl- exchange transporters CLCN4 (Kawasaki et al. 1999, Zdebik et al. 2008), CLCN5 (Zdebik et al. 2008) and CLCN6 (Neagoe et al. 2010) mediate the exchange of endosomal Cl- for cytosolic H+ across endosomal membranes, contributing to the acidification of endosomes.

Literature References
PubMed ID Title Journal Year
10564087 Identification of an acid-activated Cl(-) channel from human skeletal muscles

Kawasaki, M, Fukuma, T, Yamauchi, K, Sakamoto, H, Marumo, F, Sasaki, S

Am. J. Physiol. 1999
20466723 The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression

Neagoe, I, Stauber, T, Fidzinski, P, Bergsdorf, EY, Jentsch, TJ

J. Biol. Chem. 2010
18063579 Determinants of anion-proton coupling in mammalian endosomal CLC proteins

Zdebik, AA, Zifarelli, G, Bergsdorf, EY, Soliani, P, Scheel, O, Jentsch, TJ, Pusch, M

J. Biol. Chem. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
antiporter activity of CLCN4/5/6 [endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created