Reactome | Phosphorylation of TEC kinases by p-SYK

Phosphorylation of TEC kinases by p-SYK

Stable Identifier

R-HSA-2730833

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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BTK/ITK are activated in a two step model. In the first step they are recruited to the membrane by binding to PIP3 or, alternatively with other binding partners like SLP-76. Once at the membrane SYK or Src-kinases in the vicinity phosphorylates Y551 (Y512 in ITK) in the activation loop of the catalytic domain of BTK to fully activate it (Rawlings et al. 1996, Park et al. 1996, Kawakami et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
12573241	Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases Bäckesjö, CM, Nore, BF, Smith, CI, Mattsson, PT, Hansson, H, Westlund, A, Antonsson, P, Rönnstrand, L, Lennartsson, J, Löw, P	Biochim. Biophys. Acta	2003
8629002	Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases Park, H, Witte, ON, Kato, RM, Lin, S, Kinet, JP, Fluckiger, AC, Scharenberg, AM, Wahl, MI, Rawlings, DJ	Science	1996
7518558	Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking Miura, T, Tsukada, S, Kawakami, T, Witte, ON, Yao, L, Kawakami, Y	Mol. Cell. Biol.	1994
8630736	Regulation of Btk function by a major autophosphorylation site within the SH3 domain Park, H, Turck, CW, Witte, ON, Kinet, JP, Scharenberg, AM, Tam, C, Wahl, MI, Rawlings, DJ, Afar, DE	Immunity	1996