Phosphorylation of TEC kinases by p-SYK

Stable Identifier
R-HSA-2730833
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

BTK/ITK are activated in a two step model. In the first step they are recruited to the membrane by binding to PIP3 or, alternatively with other binding partners like SLP-76. Once at the membrane SYK or Src-kinases in the vicinity phosphorylates Y551 (Y512 in ITK) in the activation loop of the catalytic domain of BTK to fully activate it (Rawlings et al. 1996, Park et al. 1996, Kawakami et al. 1994).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Clustered p:LYN:p-FCERI:IgE:allergin:p-6Y-SYK [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed