Autophosphorylation of PKC-theta

Stable Identifier
R-HSA-2730835
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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T219, T538 at the activation loop, S676 at the turn motif and S695 at the hydrophobic motif are autophosphorylated in cis-maanner. Posphorylation of T538 is critical for kinase activation and it stabilises the open active conformation. Some studies suggest the involvement of PDK1 (3-phosphoinositide-dependent protein kinase 1) and GLK kinases in the phosphorylation T538.

Literature References
PubMed ID Title Journal Year
11772397 Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction

Liu, Y, Graham, C, Li, A, Fisher, RJ, Shaw, S

Biochem. J. 2002
22798961 Regulation of PKC-? function by phosphorylation in T cell receptor signaling

Wang, X, Chuang, HC, Li, JP, Tan, TH

Front Immunol 2012
16252004 Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes

Thuille, N, Heit, I, Fresser, F, Krumböck, N, Bauer, B, Leuthaeusser, S, Dammeier, S, Graham, C, Copeland, TD, Shaw, S, Baier, G

EMBO J. 2005
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