Reactome | Recruitment of GRB2:SOS to p-10Y-NTAL

Recruitment of GRB2:SOS to p-10Y-NTAL

Stable Identifier

R-HSA-2730837

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Upon phosphorylation NATL/LAT2 recruits GRB2:SOS complex into the receptor-signaling complex. Residues Y95, Y118, Y136, Y193, Y233 are the putative GRB2-binding sites on NTAL (Iwaki et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17993265	Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells Kovarova, M, Iwaki, S, Charles, N, Rivera, J, Tkaczyk, C, Spicka, J, Metcalfe, DD, Furumoto, Y, Gilfillan, AM, Horejsí, V, Jensen, BM	Cell. Signal.	2008