Reactome | Activation of RAC1 by VAV

Activation of RAC1 by VAV

Stable Identifier

R-HSA-2730840

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Rac1 exists in inactive state in the cytosol until the reception of extracellular signals by the cell. To be functional Rac1 is rapidly targeted to the plasma membrane upon cell stimulation. The main factors involved in this mobilisation are the Rac GEFs like VAV and phospholipids (PtdIns(4,5)P2, PtdIns(3,4,5) P3) and lipid rafts at the plasma membrane. VAV catalyses the disassociation of GDP from Rac1 by modifying the nucleotide-binding site such that GDP is released and subsequently replaced. The incoming GTP occupies the nucleotide binding site and finally displaces VAV from Rac1 (Bos et al. 2007, Bustelo et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
17540168	GEFs and GAPs: critical elements in the control of small G proteins Wittinghofer, A, Rehmann, H, Bos, JL	Cell	2007
12670394	Vav1: a key signal transducer downstream of the TCR Ardouin, L, Tybulewicz, VL, Reynolds, LF, Prisco, A	Immunol Rev	2003