Autophosphorylation of LYN kinase

Stable Identifier
R-HSA-2730862
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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LYN localized in lipid rafts undergoes an intermolecular autophosphorylation at tyrosine 397. This residue is present in the activation loop, and its phosphorylation promotes LYN kinase activity.
Literature References
PubMed ID Title Journal Year
9477973 Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity

Donella-Deana, A, Marin, O, Ruzzene, M, Brunati, AM, Cesaro, L, Pinna, LA

Biochemistry 1998
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of LYN [plasma membrane]

Orthologous Events
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