Autophosphorylation of LYN kinase

Stable Identifier
R-HSA-2730862
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LYN localized in lipid rafts undergoes an intermolecular autophosphorylation at tyrosine 396. This residue is present in the activation loop, and its phosphorylation promotes LYN kinase activity.

Literature References
PubMed ID Title Journal Year
9477973 Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity

Donella-Deana, A, Cesaro, L, Ruzzene, M, Brunati, AM, Marin, O, Pinna, LA

Biochemistry 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LYN [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created