Phosphorylation of MEK7 by MEKK1

Stable Identifier
R-HSA-2730868
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MKK7 is activated by MEKK1 and the residues serine 271 and threonine 275 are the potential phosphorylation sites that are crucial for its kinase activity (phosphorylation sites are based on sequence alignment with MAP kinase kinase family members).

Literature References
PubMed ID Title Journal Year
9639556 Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1

Cuenda, A, Dorow, DS

Biochem. J. 1998
11306453 Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers

Kim, HL, Vander Griend, DJ, Yang, X, Benson, DA, Dubauskas, Z, Yoshida, BA, Chekmareva, MA, Ichikawa, Y, Sokoloff, MH, Zhan, P, Karrison, T, Lin, A, Stadler, WM, Ichikawa, T, Rubin, MA, Rinker-Schaeffer, CW

Cancer Res. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T1400,T1412-MAP3K1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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