Reactome | Phosphorylation of SHC by SYK kinase

Phosphorylation of SHC by SYK kinase

Stable Identifier

R-HSA-2730886

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SHC is an adapter protein that has been implicated in Ras activation. Mast cells express two isoforms of 46 and 52 kDa. Both isoforms of SHC have two domains, an N-terminal phosphotyrosine-binding (PTB) domain and a C-terminal SH2 domain that allows Shc to bind to proteins containing phosphorylated tyrosine residues. Following receptor stimulation, SHC is phosphorylated by Src kinases Syk on Y239, Y240 and Y317 (p56 isoform). Both phosphotyrosines Y239 and Y317 creates the binding site for the SH2 domain of GRB2.

Literature References

PubMed ID	Title	Journal	Year
9199344	Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes Harmer, SL, DeFranco, AL	Mol Cell Biol	1997
10523831	Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction Pontén, E, Carlberg, M, Hermanson, M, Blume-Jensen, P, Lennartsson, J, Rönnstrand, L	Oncogene	1999
8663278	Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2 Zhang, C, Kinet, JP, Numerof, R, Scharenberg, AM, Paolini, R, Jabril-Cuenod, B, Beaven, MA	J. Biol. Chem.	1996