Autophosphorylation and activation of MEKK1

Stable Identifier
R-HSA-2730887
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FCERI aggregation has been shown to activate JNK as well as protein kinases upstream of JNK, such as MEKK1 (Mitogen-activated protein kinase/ERK Kinase Kinase-1) and JNK kinase (JNKK). PAK has been shown to be the upstream kinase involved in the activation of MEKK1, however no direct phosphorylation of MEKK1 by PAK is observed. Two threonine residues at positions 1400 and 1412 (analogous to 1381 and 1393 in mouse) in the activation loop of MEKK1 between the kinase subdomains VII and VIII are essential for its catalytic activity. The catalytic domain of MEKK1 is able to autophosphorylate these residues, enhancing its own activity.

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Catalyst Activity
Catalyst Activity
Title
MAP kinase kinase kinase activity of MAP3K1 [cytosol]
Physical Entity
Activity
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