NFKB1:RELA translocates from the cytosol to the nucleus

Stable Identifier
R-HSA-2730894
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Released NF-kB complex is transported to the nucleus
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The released NF-kB transcription factor (p50/p65) with unmasked nuclear localization signal (NLS) moves in to the nucleus. Once in the nucleus, NF-kB binds DNA and regulate the expression of genes encoding cytokines, cytokine receptors, and apoptotic regulators.

Literature References
PubMed ID Title Journal Year
17072321 Introduction to NF-kappaB: players, pathways, perspectives

Gilmore, TD

Oncogene 2006
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created