Phosphorylation of MEK4 by MEKK1

Stable Identifier
R-HSA-2730896
Type
Reaction
Species
Homo sapiens
Compartment
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Activated MEKK1 then phosphorylates and activates SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK) on serine and threonine residues at positions 257 and 261, respectively.

Literature References
PubMed ID Title Journal Year
7997270 Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

Zon, LI, Yan, M, Woodgett, JR, Dai, T, Templeton, DJ, Kyriakis, JM, Deak, JC

Nature 1994
7855889 MAPKs: new JNK expands the group

Davis, RJ

Trends Biochem. Sci. 1994
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T1400,T1412-MAP3K1 [cytosol]

Orthologous Events
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