CLCN3 exchanges Cl- for H+

Stable Identifier
R-HSA-2731002
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, late endosome lumen, late endosome membrane
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CLCN3 exchanges Cl- for H+
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The H+/Cl- exchange transporter CLCN3 (Borsani et al. 1995) mediates the exchange of endosomal Cl- for cytosolic H+ across late endosomal membranes, contributing to the acidification of endosomes. The activity of CLCN3 is inferred from experiments in mice (Stobrawa et al. 2001, Hara-Chikuma et al. 2005).

Literature References
PubMed ID Title Journal Year
15504734 ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

Hara-Chikuma, M, Yang, B, Sonawane, ND, Sasaki, S, Uchida, S, Verkman, AS

J. Biol. Chem. 2005
11182090 Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

Stobrawa, SM, Breiderhoff, T, Takamori, S, Engel, D, Schweizer, M, Zdebik, AA, Bösl, MR, Ruether, K, Jahn, H, Draguhn, A, Jahn, R, Jentsch, TJ

Neuron 2001
7665160 Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein

Borsani, G, Rugarli, EI, Taglialatela, M, Wong, C, Ballabio, A

Genomics 1995
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
antiporter activity of CLCN3 [late endosome membrane]
Physical Entity
CLCN3 [late endosome membrane]
Activity
antiporter activity (0015297)
Inferred From
Clcn3 exchanges Cl- for H+ (Mus musculus)
Authored
Jassal, B  (2012-12-05)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-05)
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