The H+/Cl- exchange transporter CLCN3 (Borsani et al. 1995) mediates the exchange of endosomal Cl- for cytosolic H+ across late endosomal membranes, contributing to the acidification of endosomes. The activity of CLCN3 is inferred from experiments in mice (Stobrawa et al. 2001, Hara-Chikuma et al. 2005).
Hara-Chikuma, M, Yang, B, Sonawane, ND, Sasaki, S, Uchida, S, Verkman, AS
Stobrawa, SM, Breiderhoff, T, Takamori, S, Engel, D, Schweizer, M, Zdebik, AA, Bösl, MR, Ruether, K, Jahn, H, Draguhn, A, Jahn, R, Jentsch, TJ
Borsani, G, Rugarli, EI, Taglialatela, M, Wong, C, Ballabio, A
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