TTYH1 transports cytosolic Cl- to extracellular region

Stable Identifier
R-HSA-2744349
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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TTYH1 transports cytosolic Cl- to extracellular region
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Protein tweety homolog 1 (TTYH1) has 5 isoforms. Isoform 3 (Campbell et al. 2000) mediates the Ca+-independent efflux of Cl- across plasma membranes (Suzuki & Mizuno 2004, Suzuki 2006).
Literature References
PubMed ID Title Journal Year
10950931 Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins

Suzuki, Y, Young, IG, Hida, M, Kamei, M, Campbell, HD, Sugano, S, Sutherland, GR, Claudianos, C, Woollatt, E

Genomics 2000
15010458 A novel human Cl(-) channel family related to Drosophila flightless locus

Mizuno, A, Suzuki, M

J. Biol. Chem. 2004
16219661 The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels

Suzuki, M

Exp. Physiol. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

chloride channel activity of TTYH1-3 [plasma membrane]

Physical Entity
TTYH1-3 [plasma membrane] (Homo sapiens)
Activity
chloride channel activity (GO:0005254)
Orthologous Events
TTYH1 transports cytosolic Cl- to extracellular region (Bos taurus)
TTYH1 transports cytosolic Cl- to extracellular region (Caenorhabditis elegans)
TTYH1 transports cytosolic Cl- to extracellular region (Canis familiaris)
TTYH1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)
TTYH1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)
TTYH1 transports cytosolic Cl- to extracellular region (Mus musculus)
TTYH1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)
TTYH1 transports cytosolic Cl- to extracellular region (Sus scrofa)
TTYH1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2012-12-06)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-06)
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