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Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG
Stable Identifier
R-HSA-2750187
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005).
Syndecans are also signalling molecules, interacting with cytoplasmic proteins. Most of the work done has involved syndecan-4 (Multhaupt et al. 2009). Zebrafish and murine syndecan-4 V regions bind the membrane lipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) undergoing a shape change revealed by NMR spectroscopy (Oh et al. 1998, Whiteford et al. 2008). The resulting complex is able to bind protein kinase C alpha which is persistently activated in the absence of Ca2+ (Oh et al. 1997, Lee et al. 1998, Keum et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
9115237
Multimerization of the cytoplasmic domain of syndecan-4 is required for its ability to activate protein kinase C
Couchman, JR
,
Oh, ES
,
Woods, A
J. Biol. Chem.
1997
Participants
Input
Protein Kinase C, alpha type: DAG [plasma membrane]
(Homo sapiens)
Syndecan-4:PI(4,5)P2 [plasma membrane]
(Homo sapiens)
Output
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane]
(Homo sapiens)
Participates
as an event of
Syndecan interactions (Homo sapiens)
Orthologous Events
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Canis familiaris)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Drosophila melanogaster)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Gallus gallus)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Mus musculus)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Rattus norvegicus)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Sus scrofa)
Authored
Jupe, S (2012-07-31)
Reviewed
Fuentes, J (2013-05-22)
Created
Jupe, S (2012-12-06)
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