SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5

Stable Identifier
R-HSA-2752125
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
Osteopontin binds Integrin alphaVbeta1, alphaVbeta3, alphaVbeta5
ReviewStatus
5/5
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SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5
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Osteopontin (SPP1) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It binds multiple integrins, including alphaVbeta3, alphaVbeta1 and alphaVbeta5 (Liaw et al. 1995) alpha9beta1 (Smith et al. 1996, Yokosaki et al. 1999), alpha4beta1 (Bayliss et al. 1998) and the receptor CD44 (Katagiri et al. 1999).
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Inferred From
Osteopontin binds Integrins alphaVbeta1, 3, 5 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-12-07)
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