NOTCH1 PEST domain mutants bind DLL4

Stable Identifier
R-HSA-2769000
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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NOTCH1 PEST domain mutants bind DLL4
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NOTCH1 PEST domain mutants are expected to bind to DLL4 ligand in an identical fashion to wild-type NOTCH1 (Koch et al. 2008, Hozumi et al. 2008, Benedito et al. 2009).

Literature References
PubMed ID Title Journal Year
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Roca, C, Sörensen, I, Adams, S, Gossler, A, Fruttiger, M, Adams, RH

Cell 2009
18824583 Delta-like 4 is indispensable in thymic environment specific for T cell development

Hozumi, K, Mailhos, C, Negishi, N, Hirano, K, Yahata, T, Ando, K, Zuklys, S, Holländer, GA, Shima, DT, Habu, S

J Exp Med 2008
18824585 Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Koch, U, Fiorini, E, Benedito, R, Besseyrias, V, Schuster-Gossler, K, Pierres, M, Manley, NR, Duarte, A, MacDonald, HR, Radtke, F

J Exp Med 2008
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Normal reaction
NOTCH1 binds DLL4 (Homo sapiens)
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-12-10)