NICD1 PEST domain mutants translocate from cytosol to nucleus

Stable Identifier
R-HSA-2769015
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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General
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Cytosolic NICD1 PEST domain mutants are expected to translocate to the nucleus in an identical manner to wild-type NICD1.
Literature References
PubMed ID Title Journal Year
9604939 Nuclear access and action of notch in vivo

Struhl, G, Adachi, A

Cell 1998
9651681 Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos

Schweisguth, F, Lecourtois, M

Curr Biol 1998
Participants
Participates
Normal reaction
Functional status

Gain of function of NICD1 PEST Domain Mutants [cytosol]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Reviewed
Created
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