Ficolins bind to repetitive carbohydrate structures on the target cell surface

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R-HSA-2855086
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Pathway
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Homo sapiens
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Ficolins are recognition molecules in the lectin pathway of complement activation. Three types of ficolin have been identified in humans: M-ficolin (ficolin-1, FCN1), L-ficolin (ficolin-2, FCN2) and H-ficolin (ficolin-3, FCN3). FCN2 and 3 circulate in blood plasma whereas FCN1 is locally secreted by immune response cells (Teh et al. 2000, Liu et al. 2005, Matsushita et al. 2002). Plasma ficolins circulate as complexes with MBL-associated serine proteases (MASPs). Upon binding of ficolins to carbohydrates on the target cell surface, MASPs are activated and subsequently activate the complement cascade (Matsushita et al. 2002, Gout et al. 2009). Ficolins function as trimers and larger oligomers. Ficolin peptide sequences contain an amino-terminal cysteine-rich region, a collagen-like domain, a neck region and a carboxy-terminal fibrinogen-like domain. The fibrinogen-like domain binds to pathogen- or apoptotic cell-associated molecular patterns. Different ficolins have distinct recognition specificities (Endo et al. 2007, Thiel and Gadjeva 2009, Garlatti et al. 2010).

Literature References
PubMed ID Title Journal Year
20032467 Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin

Gout, E, Garlatti, V, Smith, DF, Lacroix, M, Dumestre-Pérard, C, Lunardi, T, Martin, L, Cesbron, JY, Arlaud, GJ, Gaboriaud, C, Thielens, NM

J Biol Chem 2010
18406375 Ficolins: novel pattern recognition molecules of the innate immune response

Runza, VL, Schwaeble, W, Männel, DN

Immunobiology 2008
16116205 Human M-ficolin is a secretory protein that activates the lectin complement pathway

Liu, Y, Endo, Y, Iwaki, D, Nakata, M, Matsushita, M, Wada, I, Inoue, K, Munakata, M, Fujita, T

J. Immunol. 2005
20375619 Structural insights into the recognition properties of human ficolins

Garlatti, V, Martin, L, Lacroix, M, Gout, E, Arlaud, GJ, Thielens, NM, Gaboriaud, C

J Innate Immun 2010
11012776 M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-D-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli

Teh, C, Le, Y, Lee, SH, Lu, J

Immunology 2000
17544822 Role of ficolin in innate immunity and its molecular basis

Endo, Y, Matsushita, M, Fujita, T

Immunobiology 2007
11907111 Activation of the lectin complement pathway by H-ficolin (Hakata antigen)

Matsushita, M, Kuraya, M, Hamasaki, N, Tsujimura, M, Shiraki, H, Fujita, T

J. Immunol. 2002
19799112 Humoral pattern recognition molecules: mannan-binding lectin and ficolins

Thiel, S, Gadjeva, M

Adv. Exp. Med. Biol. 2009
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