Ficolin-1 binds to molecular patterns on the target cell surface

Stable Identifier
R-HSA-2855125
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Reaction
Species
Homo sapiens
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Ficolin-1 (M-ficolin or FCN1) was shown to localize at the cell surface of circulating monocytes and granulocytes, despite lacking an obvious transmembrane domain, (Teh C et al. 2000; Honore C et al. 2010). Ficolin-1 has also been found in human plasma (Honore C et al. 2008; Wittenborn T et al. 2010; Kjaer TR et al. 2011). Monocytes and macrophages, but not immature dendritic cells were reported to secrete Ficolin-1 into the serum (Honore C et al. 2010). Moreover, early studies revealed its presence in secretory granules of peripheral blood monocytes and granulocytes (Liu Y et al. 2005). Soluble Ficolin-1 was found to form a complex with MASP2, while cell surface-bound Ficolin-1 did not associate with MASP (Honore C et al. 2010; Kjaer TR et al. 2011).

Ficolin-1 specifically recognizes sialic acid and can bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) (Garlatti V et al. 2007; Gout E et al. 2010; Kjaer TR et al. 2011).

Literature References
PubMed ID Title Journal Year
17897951 Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch

Garlatti, V, Martin, L, Gout, E, Reiser, JB, Fujita, T, Arlaud, GJ, Thielens, NM, Gaboriaud, C

J. Biol. Chem. 2007
20375634 Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma

Wittenborn, T, Thiel, S, Jensen, L, Nielsen, HJ, Jensenius, JC

J Innate Immun 2010
20032467 Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin

Gout, E, Garlatti, V, Smith, DF, Lacroix, M, Dumestre-Pérard, C, Lunardi, T, Martin, L, Cesbron, JY, Arlaud, GJ, Gaboriaud, C, Thielens, NM

J Biol Chem 2010
16116205 Human M-ficolin is a secretory protein that activates the lectin complement pathway

Liu, Y, Endo, Y, Iwaki, D, Nakata, M, Matsushita, M, Wada, I, Inoue, K, Munakata, M, Fujita, T

J. Immunol. 2005
11012776 M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-D-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli

Teh, C, Le, Y, Lee, SH, Lu, J

Immunology 2000
20400674 Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain

Honoré, C, Rørvig, S, Hummelshøj, T, Skjoedt, MO, Borregaard, N, Garred, P

J. Leukoc. Biol. 2010
21730084 Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association

Kjaer, TR, Hansen, AG, Sørensen, UB, Nielsen, O, Thiel, S, Jensenius, JC

J. Leukoc. Biol. 2011
18343499 The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma

Honoré, C, Rørvig, S, Munthe-Fog, L, Hummelshøj, T, Madsen, HO, Borregaard, N, Garred, P

Mol. Immunol. 2008
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