Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AKR1C1 [cytosol]
Stable Identifier
R-HSA-2855253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aldo-keto reductase family 1 member C1 ecNumber1.1.1.-/ecNumber, AK1C1_HUMAN
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Prednisone ADME (Homo sapiens)
AKR1C1 hydrogenates PREDN,PREDL (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
AKRs [cytosol] (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
AKRs [cytosol] (Homo sapiens)
AKR1C1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04828 AKR1C1
Gene Names
AKR1C1, DDH, DDH1
Chain
chain:1-323
Reference Genes
BioGPS Gene:1645 AKR1C1
COSMIC (genes):AKR1C1 AKR1C1
CTD Gene:1645 AKR1C1
dbSNP Gene:1645 AKR1C1
ENSEMBL:ENSG00000187134 AKR1C1
HGNC:384 AKR1C1
Monarch:1645 AKR1C1
NCBI Gene:1645 AKR1C1
OMIM:600449 AKR1C1
UCSC:Q04828 AKR1C1
Reference Transcript
RefSeq:NM_001353.5 AKR1C1
Other Identifiers
11719171_a_at
11719172_x_at
11738244_s_at
11754189_s_at
11761068_s_at
11761114_x_at
1555854_PM_at
1555854_at
1555855_PM_at
1555855_at
1555856_PM_s_at
1555856_s_at
1645
204151_3p_x_at
204151_PM_x_at
204151_x_at
209699_PM_x_at
209699_x_at
211653_3p_x_at
211653_PM_x_at
211653_x_at
216594_3p_x_at
216594_PM_x_at
216594_x_at
3232998
3232999
3233000
3233001
3233002
3233003
3233004
3233005
3233006
3233007
3233009
3233012
3233013
3233014
3233015
3233018
3233020
3233021
3233022
3233039
3233041
3233042
3233044
3233063
3233074
3233075
3233127
3274764
3274765
3274769
3274770
3274771
3274772
3274773
3274775
3274776
3274777
3274778
3274782
3274784
3274810
3274836
32805_at
42985_r_at
60814_at
8180376
A_14_P121920
A_24_P152968
A_24_P220947
A_33_P3365117
A_33_P3403708
GE80398
GE86136
GE896252
GO:0001523
GO:0003824
GO:0004032
GO:0004033
GO:0004303
GO:0005515
GO:0005737
GO:0005829
GO:0006629
GO:0006693
GO:0006805
GO:0007586
GO:0008206
GO:0015721
GO:0016491
GO:0016655
GO:0022600
GO:0030154
GO:0030283
GO:0030299
GO:0030855
GO:0031406
GO:0032052
GO:0033703
GO:0033764
GO:0035410
GO:0042448
GO:0042574
GO:0042632
GO:0043226
GO:0044597
GO:0044598
GO:0046683
GO:0047006
GO:0047023
GO:0047024
GO:0047042
GO:0047044
GO:0047045
GO:0047086
GO:0047115
GO:0047718
GO:0070062
GO:0071395
GO:1901135
GO:2000379
HMNXSV003023750
HMNXSV003040428
HMNXSV003053466
HMNXSV003054128
Hs.306098.1.S1_3p_s_at
Hs2.213397.1.A1_3p_at
Hs2.213397.1.A2_3p_at
Hs2.213397.1.A2_3p_x_at
ILMN_1662507
ILMN_1668617
ILMN_1687757
PH_hs_0029660
PH_hs_0036384
TC10001850.hg
TC10001851.hg
TC10002924.hg
U05861_at
g187444_3p_s_at
g187444_3p_x_at
g5453542_3p_s_at
Participates
as a member of
AKRs [cytosol] (Homo sapiens)
as a candidate of
Aldo-keto reductase family [cytosol] (Homo sapiens)
Inferred To
AKR1C1 [cytosol]
(Bos taurus)
AKR1C1 [cytosol]
(Mus musculus)
AKR1C1 [cytosol]
(Rattus norvegicus)
AKR1C1 [cytosol]
(Sus scrofa)
Homologues of AKR1C4 [cytosol]
(Caenorhabditis elegans)
Homologues of AKR1C4 [cytosol]
(Dictyostelium discoideum)
Homologues of AKR1C4 [cytosol]
(Drosophila melanogaster)
Homologues of AKR1C4 [cytosol]
(Saccharomyces cerevisiae)
Homologues of AKR1C4 [cytosol]
(Schizosaccharomyces pombe)
Homologues of AKR1C4 [cytosol]
(Xenopus tropicalis)
Homologues of AKR1C1 [cytosol]
(Bos taurus)
Homologues of AKR1C1 [cytosol]
(Mus musculus)
Homologues of AKR1C1 [cytosol]
(Rattus norvegicus)
Homologues of AKR1C1 [cytosol]
(Sus scrofa)
ARY [cytosol]
(Drosophila melanogaster)
AKR1C4 [cytosol]
(Bos taurus)
AKR1C4 [cytosol]
(Caenorhabditis elegans)
AKR1C4 [cytosol]
(Dictyostelium discoideum)
AKR1C4 [cytosol]
(Drosophila melanogaster)
AKR1C4 [cytosol]
(Mus musculus)
AKR1C4 [cytosol]
(Rattus norvegicus)
AKR1C4 [cytosol]
(Saccharomyces cerevisiae)
AKR1C4 [cytosol]
(Schizosaccharomyces pombe)
AKR1C4 [cytosol]
(Sus scrofa)
AKR1C4 [cytosol]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
AK1C1_HUMAN
OpenTargets
ENSG00000187134
ENSEMBL
ENST00000380872
,
ENSP00000370254
ZINC - FDA approved
AK1C1_HUMAN
ZINC - Substances
AK1C1_HUMAN
ZINC target
Q04828
ZINC - Biogenic
AK1C1_HUMAN
PRO
Q04828
GlyGen
Q04828
PDB
3C3U
,
3NTY
,
6IJX
,
4YVP
,
3GUG
,
1MRQ
,
8JP2
,
6A7A
ZINC - Metabolites
AK1C1_HUMAN
IntEnz
1.1.1.112
,
1.1.1.210
,
1.1.1.209
,
1.3.1.20
,
1.1.1.357
,
1.1.1.51
,
1.1.1.53
,
1.1.1.62
HPA
ENSG00000187134-AKR1C1
Pharos - Targets
Q04828
ZINC - Predictions - Purchasable
AK1C1_HUMAN
HMDB Protein
HMDBP00386
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26045 PTPN3
3
PTPN3 [cytosol]
(R-HSA-8867650)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [plasma membrane]
(R-HSA-5490317)
0.718
6
UniProt:P51857 AKR1D1
1
AKR1D1 [cytosol]
(R-HSA-191975)
0.589
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:P42330 AKR1C3
1
AKR1C3 [cytosol]
(R-HSA-2142714)
0.527
2
UniProt:P52895 AKR1C2
1
AKR1C2 [cytosol]
(R-HSA-3229259)
0.527
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text