FCERI mediated MAPK activation

Stable Identifier
R-HSA-2871796
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, nucleoplasm, plasma membrane
ReviewStatus
5/5
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FCERI mediated MAPK activation
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Formation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as the sequence that leads to degranulation. However, the pathways that lead to cytokine production require the guanine-nucleotide-exchange factors SOS and VAV that regulate GDP-GTP exchange of RAS. After its activation, RAS positively regulates the RAF-dependent pathway that leads to phosphorylation and, in part, activation of the mitogen-activated protein kinases (MAPKs) extracellular-signal-regulated kinase 1 (ERK1) and ERK2 (Gilfillan & Tkaczyk 2006).
Literature References
PubMed ID Title Journal Year
17122878 Intracellular signaling pathways in IgE-dependent mast cell activation

Panaszek, B, Kope?, A, Fal, AM

Arch. Immunol. Ther. Exp. (Warsz.) 2006
19909365 Adapters in the organization of mast cell signaling

Lessmann, E, Rivera, J, Alvarez-Errico, D

Immunol. Rev. 2009
19290926 The tyrosine kinase network regulating mast cell activation

Rivera, J, Gilfillan, AM

Immunol. Rev. 2009
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Cross References
BioModels Database
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-21)
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