FCERI mediated Ca+2 mobilization

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Increase of intracellular calcium in mast cells is most crucial for mast cell degranulation. Elevation of intracellular calcium is achieved by activation of PLC-gamma. Mast cells express both PLC-gamma1 and PLC-gamma2 isoforms and activation of these enzymes leads to conversion of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol triphosphate (IP3) and diacylglycerol (DAG). The production of IP3 leads to mobilization of intracellular Ca+2, which later results in a sustained Ca+2 flux response that is maintained by an influx of extracellular Ca+2. In addition to degranulation, an increase in intracellular calcium concentration also activates the Ca2+/calmodulin-dependent serine phosphatase calcineurin. Calcineurin dephosphorylates the nuclear factor for T cell activation (NFAT) which exposes nuclear-localization signal sequence triggering translocation of the dephosphorylated NFAT-CaN complex to the nucleus. Once in the nucleus, NFAT regulates the transcription of several cytokine genes (Kambayashi et al. 2007, Hoth & Penner 1992, Ebinu et al. 2000, Siraganian et al).

Literature References
PubMed ID Title Journal Year
10807788 RasGRP links T-cell receptor signaling to Ras

Ebinu, JO, Stang, SL, Teixeira, C, Bottorff, DA, Hooton, J, Blumberg, PM, Barry, M, Bleakley, RC, Ostergaard, HL, Stone, JC

Blood 2000
17336609 Proximal signaling events in Fc epsilon RI-mediated mast cell activation

Kambayashi, T, Koretzky, GA

J. Allergy Clin. Immunol. 2007
1309940 Depletion of intracellular calcium stores activates a calcium current in mast cells

Hoth, M, Penner, R

Nature 1992
Participant Of
Orthologous Events
Cross References
BioModels Database