Reactome | FCERI mediated NF-kB activation

FCERI mediated NF-kB activation

Stable Identifier

R-HSA-2871837

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, nucleoplasm, plasma membrane

ReviewStatus

5/5

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The increase in intracellular Ca+2 in conjunction with DAG also activates PKC and RasGRP, which inturn contributes to cytokine production by mast cells (Kambayashi et al. 2007). Activation of the FCERI engages CARMA1, BCL10 and MALT1 complex to activate NF-kB through PKC-theta (Klemm et al. 2006, Chen et al. 2007). FCERI stimulation leads to phosphorylation, and degradation of IkB which allows the release and nuclear translocation of the NF-kB proteins. Activation of the NF-kB transcription factors then results in the synthesis of several cytokines. NF-kB activation by FCERI is critical for proinflammatory cytokine production during mast cell activation and is crucial for allergic inflammatory diseases (Klemm et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16432253	The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation Klemm, S, Gutermuth, J, Hültner, L, Sparwasser, T, Behrendt, H, Peschel, C, Mak, TW, Jakob, T, Ruland, J	J. Exp. Med.	2006
17336609	Proximal signaling events in Fc epsilon RI-mediated mast cell activation Kambayashi, T, Koretzky, GA	J. Allergy Clin. Immunol.	2007