Reactome | EXOC3 [secretory granule membrane]

EXOC3 [secretory granule membrane]

Stable Identifier

R-HSA-2872286

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Locations in the PathwayBrowser for interactor UniProt:Q9BZL4 PP12C

Expand all

External Reference Information

External Reference

UniProt:O60645 EXOC3

Gene Names

EXOC3, SEC6, SEC6L1

Chain

chain:1-745

Reference Genes

BioGPS Gene:11336 EXOC3

COSMIC (genes):EXOC3 EXOC3

CTD Gene:11336 EXOC3

dbSNP Gene:11336 EXOC3

ENSEMBL:ENSG00000180104 EXOC3

HGNC:30378 EXOC3

Monarch:11336 EXOC3

NCBI Gene:11336 EXOC3

OMIM:608186 EXOC3

UCSC:O60645 EXOC3

Reference Transcript

Other Identifiers

11336

11716926_a_at

16982579

212630_PM_at

212630_at

228847_PM_at

228847_at

2798680

2798681

2798682

2798683

2798684

2798685

2798686

2798688

2798689

2798690

2798691

2798692

2798693

2798694

2798695

2798696

2798698

2798699

2798700

2798701

2798702

2798703

2798704

2798705

2798706

2798707

2798708

2798709

2798710

2798711

2798712

2798713

2798714

2798715

2798716

2798717

2798720

2798721

2798722

2798725

2798727

2798728

37597_s_at

8104201

A_14_P137894

A_23_P389676

A_23_P93046

GE54509

GO:0000145

GO:0000149

GO:0000281

GO:0000910

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0006887

GO:0006904

GO:0015031

GO:0016192

GO:0030426

GO:0030496

GO:0030667

GO:0042734

GO:0042995

GO:0043005

GO:0043226

GO:0045296

GO:0048471

GO:0051601

GO:0061024

GO:0090148

GO:0090522

HMNXSV003048862

Hs.107614.1.A1_3p_at

Hs.8088.0.A1_3p_at

ILMN_1789419

PH_hs_0030371

PH_hs_0036049

TC05000006.hg

TC05002173.hg

Participates

as a component of

Exocyst Complex [plasma membrane] (Homo sapiens)

as an input of

Exocyst complex formation (Homo sapiens)

Other forms of this molecule

EXOC3 [cytosol]

Inferred To

sec-6 [secretory granule membrane] (Caenorhabditis elegans)

exoc3 [secretory granule membrane] (Dictyostelium discoideum)

EXOC3 [secretory granule membrane] (Bos taurus)

EXOC3 [secretory granule membrane] (Canis familiaris)

EXOC3 [secretory granule membrane] (Gallus gallus)

Exoc3 [secretory granule membrane] (Mus musculus)

Exoc3 [secretory granule membrane] (Rattus norvegicus)

Sec6 [secretory granule membrane] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000180104

ENSEMBL

ENSP00000425587, ENST00000315013, ENST00000512944, ENSP00000323377

HPA

ENSG00000180104-EXOC3

PRO

O60645

Pharos - Targets

O60645

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.725	5
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.725	6
UniProt:Q96KP1 EXOC2	2	EXOC2 [cytosol] (R-HSA-5623376) EXOC2 [plasma membrane] (R-HSA-264887)	0.725	6
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.638	5
UniProt:Q9UPT5 EXOC7	2	EXOC7 [cytosol] (R-HSA-5623386) EXOC7 [plasma membrane] (R-HSA-2872288)	0.638	4
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.638	4
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.638	4
UniProt:Q96IK5 GMCL1			0.556	3
UniProt:Q9BZL4 PP12C			0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) SDC2 [Golgi lumen] (R-HSA-2054101) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397)	0.527	2
UniProt:Q96NL6 SCLT1	1	SCLT1 [cytosol] (R-HSA-5620935)	0.527	2
UniProt:Q9Y496 KIF3A	3	KIF3A [cilium] (R-HSA-5610394) KIF3A [cytosol] (R-HSA-984767) KIF3A [ciliary tip] (R-HSA-5625377)	0.527	3
UniProt:Q13563 PKD2	3	PKD2 [Golgi membrane] (R-HSA-5623393) PKD2 [Golgi-associated vesicle membrane] (R-HSA-5623411) PKD2 [ciliary membrane] (R-HSA-5623409)	0.527	2
UniProt:Q15643 TRIP11	4	TRIP11 [transport vesicle] (R-HSA-8847847) TRIP11 [Golgi membrane] (R-HSA-5617602) TRIP11(2-1724)-FLT3(594-993) fusion [cytosol] (R-HSA-9703323) TRIP11(2-1724)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703304)	0.527	3
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.527	2
UniProt:Q8WXW3 PIBF1			0.527	2
UniProt:Q8IWJ2 GCC2	3	GCC2 [cytosol] (R-HSA-6813880) GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9713455) GCC2(1-1204)-ALK(1059-1620) fusion [cytosol] (R-HSA-9713458)	0.527	3
UniProt:Q99666 RGPD5			0.527	2
UniProt:Q9BQD3 KXDL1			0.527	2
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.527	4
UniProt:Q9BQ69 MACD1			0.527	2
UniProt:P0DJD1 RGPD2			0.527	2
UniProt:Q13445 TMED1			0.508	2
UniProt:Q9Y2D4 EXC6B			0.508	3

Cite Us!