Reactome | SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol

SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol

Stable Identifier

R-HSA-2872498

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol

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The microsomal Na+/(PO4)3- transporter isoform 1 (SLC17A3, NPT4 isoform 1) is a member of the anion-cation symporter family. It is expressed in liver, kidney and intestine and may function as a cotransporter of sodium (Na+) and phosphate ((PO4)3- or Pi) across the ER membrane (Melis et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15505377	NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic Mancini, GM, Verbeek, E, Benedetti, A, Smit, GP, Verheijen, F, Melis, D, Havelaar, AC	J. Inherit. Metab. Dis.	2004