SLC9B2 exchanges Na+, Li+ for H+

Stable Identifier
R-HSA-2889070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondrial sodium/hydrogen exchanger 9B2 (SLC9B2, aka NHA2) is ubiquitously expressed and mediates the electrogenic exchange of 1 Na+ (or 1 Li+) for 2 H+ across the inner mitochondrial membrane (Xiang et al. 2007, Taglicht et al. 1993). This transport is thought to play a role in salt homeostasis and pH regulation in humans.

Literature References
PubMed ID Title Journal Year
18000046 A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension

Xiang, M, Feng, M, Muend, S, Rao, R

Proc. Natl. Acad. Sci. U.S.A. 2007
8383669 Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli

Taglicht, D, Padan, E, Schuldiner, S

J. Biol. Chem. 1993
Participants
Participates
Catalyst Activity

monovalent cation:proton antiporter activity of SLC9B2 [mitochondrial inner membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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