POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

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R-HSA-2892247
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Homo sapiens
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POU5F1 (OCT4), SOX2, and NANOG bind elements in the promoters of target genes. The target genes of each transcription factor overlap extensively: POU5F1, SOX2, and NANOG co-occupy at least 353 genes (Boyer et al. 2005). About half of POU5F1 targets also bind SOX2 and about 90% of these also bind NANOG (Boyer et al. 2005). Upon binding the transcription factors activate expression of one subset of target genes and repress another subset (Kim et al. 2006, Matoba et al. 2006, Player et al. 2006, Babaie et al. 2007). The targets listed in this module are those that have been described as composing activated genes in the core transcriptional network of pluripotent stem cells (Assou et al. 2007, Chavez et al. 2009, Jung et al. 2010). Inferences from mouse to human have been made with caution because of significant differences between the two species (Ginis et al. 2004).

Literature References
PubMed ID Title Journal Year
17183653 Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling

Matoba, R, Niwa, H, Masui, S, Ohtsuka, S, Carter, MG, Sharov, AA, Ko, MS

PLoS One 2006
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
16846370 Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines

Player, A, Wang, Y, Bhattacharya, B, Rao, M, Puri, RK, Kawasaki, ES

Stem Cells Dev 2006
15110706 Differences between human and mouse embryonic stem cells

Ginis, I, Luo, Y, Miura, T, Thies, S, Brandenberger, R, Gerecht-Nir, S, Amit, M, Hoke, A, Carpenter, MK, Itskovitz-Eldor, J, Rao, MS

Dev Biol 2004
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Jung, M, Peterson, H, Chavez, L, Kahlem, P, Lehrach, H, Vilo, J, Adjaye, J

PLoS One 2010
19604364 In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach

Chavez, L, Bais, AS, Vingron, M, Lehrach, H, Adjaye, J, Herwig, R

BMC Genomics 2009
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
17204602 A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas

Assou, S, Le Carrour, T, Tondeur, S, Ström, S, Gabelle, A, Marty, S, Nadal, L, Pantesco, V, Réme, T, Hugnot, JP, Gasca, S, Hovatta, O, Hamamah, S, Klein, B, De Vos, J

Stem Cells 2007
16819296 Profiling of differentially expressed genes in human stem cells by cDNA microarray

Kim, CG, Kim, CG, Lee, JJ, Jung, DY, Jeon, J, Heo, HS, Kang, HC, Shin, JH, Cho, YS, Cha, KJ, Do, BR, Kim, KS, Kim, HS

Mol Cells 2006
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