NOTCH1 HD+PEST domain mutants bind JAG1

Stable Identifier
R-HSA-2900743
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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It has not been directly shown that JAG1 binds to and activates NOTCH1 HD (heterodimerization) domain mutants, but NOTCH1 HD mutants and in cis HD and PEST domain NOTCH1 mutants are expected to respond to JAG1 like NOTCH1 HD domain mutants respond to DLL1 (Malecki et al. 2006).

Literature References
PubMed ID Title Journal Year
16738328 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Malecki, MJ, Sanchez-Irizarry, C, Mitchell, JL, Histen, G, Xu, ML, Aster, JC, Blacklow, SC

Mol. Cell. Biol. 2006
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created